{"id":"W4412043895","doi":"10.1111/cge.70020","title":"Prenatal Cell‐Free DNA Screening With Fetal Enrichment Enables Sampling From 8 Weeks of Gestational Age","year":2025,"lang":"en","type":"article","venue":"Clinical Genetics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Hôpital Saint-François d'Assise; Université Laval","funders":"Génome Québec; Université Laval","keywords":"Cell-free fetal DNA; Medicine; Fetus; Gestation; Obstetrics; Gestational age; Pregnancy; Aneuploidy; Prenatal screening; Prenatal diagnosis; Chorionic villus sampling; Andrology; Physiology; Gynecology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000833049,0.0002432572,0.0002989355,0.0005891937,0.0002311218,0.0003123742,0.0002858584,0.0003087834,0.00133668],"category_scores_gemma":[0.002146773,0.0001685078,0.0001628704,0.0002594755,0.0002356062,0.0001604976,0.0003149585,0.0001905395,0.0004268523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143661,"about_ca_system_score_gemma":0.0002554359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001893147,"about_ca_topic_score_gemma":0.00205514,"domain_scores_codex":[0.9992862,0.0002948931,0.00004008904,0.000126394,0.0001558016,0.00009656857],"domain_scores_gemma":[0.999273,0.0004229741,0.0001192381,0.00007477309,0.00006569347,0.00004439734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001425895,0.0001969087,0.5420194,0.000217092,0.0000610787,0.001265477,0.0005587639,0.0004722921,0.3477811,0.0004591592,0.0004447014,0.1050982],"study_design_scores_gemma":[0.00004317509,0.00248572,0.7085224,0.0001167484,0.000094102,0.0092665,0.0004813228,0.002193423,0.2646018,0.0005013263,0.01165106,0.00004234712],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794144,0.00223477,0.01546821,0.0001319345,0.0000276398,0.0001114365,0.000430173,0.00005738088,0.002123993],"genre_scores_gemma":[0.9853317,0.001099218,0.01165815,0.0001030155,0.00001250645,0.00009036505,0.0005405691,0.00001255977,0.001151887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001893147,"threshold_uncertainty_score":0.00447166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05240217796607394,"score_gpt":0.3450990653969391,"score_spread":0.2926968874308651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}