{"id":"W4412056519","doi":"10.1016/j.mcpro.2026.101562","title":"Expanding the Global Map of Protein Post Translational Modifications with Immunoaffinity Enrichment and nDIA Analysis on the Orbitrap Astral Mass Spectrometer","year":2025,"lang":"en","type":"preprint","venue":"Molecular & Cellular Proteomics","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada)","funders":"","keywords":"Orbitrap; Mass spectrometry; Chemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005352066,0.0007334698,0.0004527019,0.001135201,0.00047649,0.0006230673,0.0004324563,0.0004464567,0.002102845],"category_scores_gemma":[0.0005523536,0.0002504474,0.0004905243,0.0008800161,0.0002796505,0.0005114996,0.0006012291,0.0009881444,0.0009490394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003525769,"about_ca_system_score_gemma":0.0005118526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008518691,"about_ca_topic_score_gemma":0.001800414,"domain_scores_codex":[0.9996104,0.00004522273,0.0000307286,0.0001205838,0.0001423239,0.00005081876],"domain_scores_gemma":[0.9996604,0.00006446959,0.00006786926,0.00005538556,0.0001176814,0.00003405486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006792763,0.00001726538,0.001107004,0.00008879429,0.00002404669,0.00006782652,0.00002765219,0.00008046198,0.9911107,0.0001561771,0.0001812157,0.007070959],"study_design_scores_gemma":[0.00001687916,0.0002099458,0.02755297,0.00003444231,0.00009045999,0.00118646,0.00009018221,0.007479285,0.9521536,0.0003801171,0.01077366,0.00003199642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7863517,0.004298664,0.1937444,0.0006184243,0.0001267986,0.0002387444,0.004616682,0.002664811,0.007339718],"genre_scores_gemma":[0.6252742,0.003225595,0.3552871,0.0008183704,0.00006513458,0.0003957084,0.008623505,0.0006048023,0.005705515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002102845,"threshold_uncertainty_score":0.007034719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009996596327650329,"score_gpt":0.2414410233818871,"score_spread":0.2314444270542368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}