{"id":"W4412066370","doi":"10.1186/s40478-025-02072-2","title":"Immunoelectron microscopy and biochemical studies using three anti-tau antibodies in human brains: associations between pTau and ribosomes","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health","keywords":"Immunoelectron microscopy; Pathology; Ribosome; Antibody; Medicine; Neuroscience; Biology; Chemistry; Immunohistochemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989809,0.0001514554,0.0002359222,0.000111373,0.0004816381,0.00005182442,0.0003127066,0.0001118091,7.283865e-7],"category_scores_gemma":[0.0004316235,0.0001466966,0.00004419243,0.0001912354,0.0004802525,0.00001296008,0.0007316251,0.0001554555,3.380981e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002128624,"about_ca_system_score_gemma":0.00003823723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000150167,"about_ca_topic_score_gemma":0.00003281901,"domain_scores_codex":[0.998944,0.0002322588,0.0002847075,0.0002978893,0.00005371717,0.0001873759],"domain_scores_gemma":[0.9989622,0.000114059,0.0001128962,0.0006905991,0.00008077495,0.00003947436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000003984517,0.00005524612,0.3086146,0.000008045397,0.00002749,7.536966e-7,0.00005281285,0.000001219258,0.6906144,0.0003514012,0.0001032367,0.0001667849],"study_design_scores_gemma":[0.0004320767,0.00005694938,0.9811067,0.00003331039,0.00005612542,0.000004497681,0.0001253091,0.00004908611,0.01644524,0.0009978436,0.0005325129,0.0001603485],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878706,0.00985035,0.00005506932,0.001708911,0.00001963815,0.0001994869,0.0000512895,0.00002373499,0.0002209189],"genre_scores_gemma":[0.9944816,0.00390246,0.001036614,0.0002886723,0.00001731553,0.00001580952,0.0002064776,0.00001023978,0.00004083324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6741691,"threshold_uncertainty_score":0.5982112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04869142880408737,"score_gpt":0.3673028343247591,"score_spread":0.3186114055206717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}