{"id":"W4412066370","doi":"10.1186/s40478-025-02072-2","title":"Immunoelectron microscopy and biochemical studies using three anti-tau antibodies in human brains: associations between pTau and ribosomes","year":2025,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health","keywords":"Immunoelectron microscopy; Pathology; Ribosome; Antibody; Medicine; Neuroscience; Biology; Chemistry; Immunohistochemistry; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365978,0.0003026235,0.0001435895,0.0006343887,0.0003221756,0.0001892922,0.000182745,0.0003214562,0.0009029438],"category_scores_gemma":[0.0001831799,0.0001639145,0.0001981377,0.0002843973,0.0002929234,0.0002306377,0.0002017116,0.0002090762,0.0003268207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572231,"about_ca_system_score_gemma":0.0001197931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008748136,"about_ca_topic_score_gemma":0.001033632,"domain_scores_codex":[0.9999086,0.00001479497,0.00001045957,0.00002711176,0.00001835639,0.00002067119],"domain_scores_gemma":[0.9998968,0.00002004066,0.00002835435,0.00001313855,0.00002384171,0.00001789061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002095691,0.00003727949,0.005183337,0.00009367934,0.00001572837,0.001076596,0.0001766028,0.00003528935,0.9900771,0.0001155786,0.00003368875,0.002945635],"study_design_scores_gemma":[0.00003825488,0.001774034,0.3745866,0.00005927281,0.0001492556,0.01828143,0.0009110348,0.001284788,0.597573,0.000626003,0.004689598,0.00002672252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994522,0.001802148,0.002145848,0.00002811943,0.00001349809,0.00001962523,0.00007564307,0.00003050264,0.00136252],"genre_scores_gemma":[0.992165,0.001690399,0.004509754,0.00003648766,0.00001246509,0.00003367208,0.0002155522,0.00001065335,0.001326098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009029438,"threshold_uncertainty_score":0.003020644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04869142880408737,"score_gpt":0.3673028343247591,"score_spread":0.3186114055206717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}