{"id":"W4412073469","doi":"10.1038/s41698-025-01025-1","title":"Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma","year":2025,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Telesta Therapeutics (Canada)","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health; U.S. Department of Defense","keywords":"Metastatic melanoma; Melanoma; Medicine; Dermatology; Internal medicine; Oncology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352496,0.0005288548,0.000427609,0.0006300083,0.0007648945,0.0004093087,0.0003369849,0.001281643,0.0011141],"category_scores_gemma":[0.000762671,0.000188312,0.0003860978,0.000333563,0.0003930921,0.0004231784,0.0003126626,0.00126637,0.0002704629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005981521,"about_ca_system_score_gemma":0.0003481242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002211674,"about_ca_topic_score_gemma":0.005095149,"domain_scores_codex":[0.9998692,0.00001353728,0.00001344893,0.00004654734,0.00002523476,0.00003190587],"domain_scores_gemma":[0.9996062,0.00007040059,0.00006177694,0.00002196651,0.00003423429,0.0002055837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002958175,0.0001153655,0.02320225,0.00006331768,0.00003140367,0.9505999,0.0003416663,0.0004586227,0.01355131,0.0003451278,0.001147686,0.009847395],"study_design_scores_gemma":[0.00002328962,0.0006225494,0.04127669,0.00002171022,0.0000485765,0.951189,0.0001506226,0.001320165,0.00351664,0.0002746886,0.001535462,0.00002057908],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980965,0.001845368,0.001803022,0.003768442,0.0001379561,0.000101096,0.0003819086,0.0001876352,0.01080958],"genre_scores_gemma":[0.9963529,0.0004149764,0.0005724026,0.0006257268,0.00005691412,0.000007521176,0.00009474318,0.0000154183,0.001859399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002211674,"threshold_uncertainty_score":0.004397631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024201955165141,"score_gpt":0.2824535413533765,"score_spread":0.272211521801725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}