{"id":"W4412076293","doi":"10.1016/s1473-3099(25)00236-1","title":"Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Moderna","keywords":"Immunogenicity; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Double blind; Messenger RNA; Placebo; Biology; Immunology; Antibody; Gene; Internal medicine; Genetics; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002181622,0.001315256,0.00284949,0.0002963171,0.0003204479,0.0009251694,0.0007813572,0.001905929,0.003751555],"category_scores_gemma":[0.00210253,0.0005288757,0.002333029,0.0003684282,0.001335199,0.001027137,0.0002915429,0.002411508,0.0007235341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008399776,"about_ca_system_score_gemma":0.0009464434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008678169,"about_ca_topic_score_gemma":0.0008219269,"domain_scores_codex":[0.9986802,0.0006316362,0.0001018188,0.0002292278,0.0001720697,0.0001851764],"domain_scores_gemma":[0.9987685,0.0004718119,0.0003522948,0.00008702544,0.00009613033,0.0002242187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9764535,0.003914704,0.000448259,0.0005404945,0.0007670986,0.000017184,0.00003559702,0.0002325276,0.004690265,0.00005499694,0.0002725522,0.0125727],"study_design_scores_gemma":[0.7425622,0.2494504,0.003438039,0.00006614682,0.001105206,0.00004159453,0.00002784969,0.0005602801,0.001900763,0.000183222,0.0006337636,0.00003054754],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912142,0.0053022,0.0005012992,0.0002042201,0.0003224146,0.001007863,0.0004584252,0.00004233889,0.0009470366],"genre_scores_gemma":[0.9919916,0.002529122,0.001040976,0.0003736539,0.0003695307,0.001353174,0.0007487519,0.00002179735,0.001571369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003751555,"threshold_uncertainty_score":0.01255018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06267091285717495,"score_gpt":0.3584585290216614,"score_spread":0.2957876161644864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}