{"id":"W4412076293","doi":"10.1016/s1473-3099(25)00236-1","title":"Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Moderna","keywords":"Immunogenicity; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Double blind; Messenger RNA; Placebo; Biology; Immunology; Antibody; Gene; Internal medicine; Genetics; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130158,0.0004453251,0.001693499,0.0002232016,0.0005994802,0.0001729555,0.0004614296,0.0001349183,0.00003861349],"category_scores_gemma":[0.003506978,0.0002372432,0.0003948772,0.0008192345,0.0001876516,0.0001900971,0.0002004768,0.0004870777,0.000006879545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245144,"about_ca_system_score_gemma":0.001140007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002135508,"about_ca_topic_score_gemma":0.001235106,"domain_scores_codex":[0.9964273,0.0009284921,0.0009042294,0.0006250184,0.0006135923,0.000501373],"domain_scores_gemma":[0.993376,0.004422376,0.0005140553,0.001211819,0.0003308892,0.0001448265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9677829,0.002109293,0.005725577,0.000102728,0.00220302,0.00002602237,0.0005294901,0.0001370655,0.01542015,0.0000666886,0.003277053,0.002619979],"study_design_scores_gemma":[0.9688554,0.001560488,0.01141653,0.0001399255,0.002094378,0.00001811616,0.0001554781,0.002177033,0.004978279,0.0002542158,0.008095347,0.0002548489],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812368,0.002597932,0.0004558548,0.006480776,0.0002373369,0.007746151,0.0005594892,0.0001895222,0.000496146],"genre_scores_gemma":[0.9821911,0.0002499431,0.00001573369,0.01549111,0.001073186,0.0006695659,0.0002228087,0.00003537984,0.00005119384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01044187,"threshold_uncertainty_score":0.9674498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06267091285717495,"score_gpt":0.3584585290216614,"score_spread":0.2957876161644864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}