{"id":"W4412078443","doi":"10.1007/s12012-025-10037-z","title":"Safety of Permissive Cardiotoxicity of Trastuzumab in Patients with Breast Cancer: A Systematic Review and Meta-Analysis","year":2025,"lang":"en","type":"review","venue":"Cardiovascular Toxicology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Benha University","keywords":"Medicine; Cardiotoxicity; Trastuzumab; Breast cancer; Internal medicine; Asymptomatic; Oncology; Ejection fraction; Cancer; Cochrane Library; Heart failure; Meta-analysis; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_broad"],"category_scores_codex":[0.001284414,0.0006474021,0.02679478,0.0007709352,0.00003610058,0.00000560334,0.0002206572,0.0005893277,0.00006547839],"category_scores_gemma":[0.000235407,0.0004353233,0.01090383,0.001992709,0.0002233835,0.00005339518,0.00007892888,0.0004696169,5.196305e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004406338,"about_ca_system_score_gemma":0.0007827923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006521495,"about_ca_topic_score_gemma":0.00002095052,"domain_scores_codex":[0.9950647,0.001443495,0.00174406,0.0007859059,0.0006514217,0.0003104332],"domain_scores_gemma":[0.9966865,0.0003157932,0.0009066807,0.001402675,0.0005567324,0.0001316674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00003045464,0.00009909009,0.0000339635,0.5692559,0.4257679,0.00001154249,0.0000288962,0.00001935538,7.691071e-7,0.000006496233,0.000005284446,0.004740316],"study_design_scores_gemma":[0.001203294,0.0001355395,0.0004517294,0.06937503,0.9274063,0.00009947125,0.00001399365,6.636309e-7,0.00002658587,0.000001116595,0.0009932321,0.0002930625],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001173154,0.9906008,0.0001359298,0.00003895225,0.00003081161,0.007931524,0.0009871697,0.00001496801,0.0001425288],"genre_scores_gemma":[0.004323666,0.994224,0.00005524017,0.0001319073,0.00001769419,0.0009461061,0.0001893329,0.00004218343,0.00006991734],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5016384,"threshold_uncertainty_score":0.9998099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288166021900965,"score_gpt":0.2973597195906656,"score_spread":0.2744780593716559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}