{"id":"W4412085155","doi":"10.1016/j.imlet.2025.107059","title":"The CSF transcriptome in adults with pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality","year":2025,"lang":"en","type":"article","venue":"Immunology Letters","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; University College London Hospitals NHS Foundation Trust; Wellcome Trust; Academy of Medical Sciences; National Institute for Health and Care Research; Cancer Research UK; University College London; Imperial College London; International Seafood Sustainability Foundation","keywords":"Transcriptome; Meningitis; Immunology; Host (biology); Medicine; Streptococcus pneumoniae; Biology; Microbiology; Pediatrics; Gene; Genetics; Gene expression; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003612258,0.0002588085,0.0003925583,0.0001921215,0.0004574905,0.00004042858,0.0002623643,0.0002236654,0.00004560007],"category_scores_gemma":[0.00007014726,0.0001709925,0.00006532635,0.0003479085,0.0007138805,0.0001401249,0.00004441132,0.0004698985,0.0000200585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001308349,"about_ca_system_score_gemma":0.00007344758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002804329,"about_ca_topic_score_gemma":0.00151,"domain_scores_codex":[0.9979859,0.0007375691,0.0004166448,0.0003348159,0.000024206,0.0005008865],"domain_scores_gemma":[0.9989292,0.0004488472,0.0001585167,0.000381016,0.00006980626,0.00001259282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002627129,0.0001069432,0.2129375,0.000008450411,0.0008789414,0.00001751425,0.0002942272,0.000002302479,0.7821705,0.0003219495,0.0005518456,0.00008267679],"study_design_scores_gemma":[0.004766448,0.0002683476,0.9628463,0.0002716258,0.00007738552,0.0000457424,0.0003166981,6.097366e-7,0.02819675,0.00001858024,0.002976133,0.0002153838],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941145,0.0006564378,0.00000946193,0.003654652,0.0006481693,0.0005206089,0.00005666884,0.0001178381,0.0002216711],"genre_scores_gemma":[0.9988512,0.00006058965,0.000005060132,0.0003460432,0.00001098636,0.0001945702,0.0001109608,0.00001664431,0.0004039405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7539737,"threshold_uncertainty_score":0.6972871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008160407534721147,"score_gpt":0.2358093009625473,"score_spread":0.2276488934278262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}