{"id":"W4412085379","doi":"10.1111/epi.18540","title":"Distinct impacts of sodium channel blockers on the strength–duration properties of human motor cortex neurons","year":2025,"lang":"en","type":"article","venue":"Epilepsia","topic":"Transcranial Magnetic Stimulation Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Academy of Medical Sciences","keywords":"Lacosamide; Sodium channel; Rheobase; Carbamazepine; Transcranial magnetic stimulation; Neuroscience; Motor cortex; Sodium channel blocker; Anticonvulsant; Anesthesia; Medicine; Psychology; Electrophysiology; Pharmacology; Chemistry; Stimulation; Epilepsy; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265955,0.0001170912,0.0002277163,0.00009342757,0.0000578588,0.0001518609,0.00008413054,0.000164214,0.001152359],"category_scores_gemma":[0.0004762039,0.0000523104,0.0000950824,0.00006310373,0.00015551,0.00009887731,0.0001023004,0.0001573957,0.0001113637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000136058,"about_ca_system_score_gemma":0.0001358974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006208136,"about_ca_topic_score_gemma":0.001283936,"domain_scores_codex":[0.9998994,0.00001989636,0.00001044386,0.00002205614,0.00003185925,0.00001633758],"domain_scores_gemma":[0.9998769,0.00004045264,0.00003616364,0.000009921537,0.00001745414,0.00001920109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004799269,0.0002032159,0.01031826,0.0001065328,0.00005391565,0.0001511104,0.00005353496,0.000198525,0.9666873,0.00003348858,0.00003916589,0.01735562],"study_design_scores_gemma":[0.0002884826,0.02161804,0.4323576,0.00002482931,0.000246816,0.001247483,0.0001612193,0.001747507,0.5410275,0.0001289891,0.001133613,0.00001784708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989862,0.000384378,0.0003330531,0.00001276538,0.000003140589,0.00001329886,0.00004110941,0.00000668544,0.0002194202],"genre_scores_gemma":[0.9993671,0.0001893797,0.0002146639,0.00001925536,0.000002892378,0.00001017071,0.00003559772,0.000002080523,0.0001589396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152359,"threshold_uncertainty_score":0.00385505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215902103918025,"score_gpt":0.276226136063989,"score_spread":0.2340671150248087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}