{"id":"W4412086527","doi":"10.1001/jamanetworkopen.2025.19236","title":"Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia; Queen's University","funders":"National Cancer Institute; Canadian Institutes of Health Research; Cancer Research UK; World Health Organization","keywords":"Breast cancer; Medicine; Oncology; Internal medicine; Body mass index; Overweight; Estrogen; Population; Cancer; Hormone therapy; Progestin; Endocrinology; Physiology; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121424,0.000139155,0.0003396194,0.00004520241,0.0001261642,0.0001386063,0.0001758148,0.00007032778,0.0003216742],"category_scores_gemma":[0.00001135744,0.0001132279,0.00003924044,0.0003462022,0.00005556077,0.0001148779,0.0002886574,0.0002134185,0.00001385998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153328,"about_ca_system_score_gemma":0.0002786346,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007289767,"about_ca_topic_score_gemma":0.001267584,"domain_scores_codex":[0.9990999,0.00002883803,0.0001907696,0.0002854282,0.0001046102,0.000290463],"domain_scores_gemma":[0.9994269,0.00004104086,0.00006063567,0.0002794936,0.00006451182,0.0001273987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001379626,0.00006148805,0.5391414,0.00006626503,0.0001764619,0.00008063488,0.0001247519,0.00002626518,0.00006874396,0.00086258,0.1546391,0.3033727],"study_design_scores_gemma":[0.001544897,0.00005591424,0.8282703,0.0003072783,0.0001124264,0.00007589094,0.00004549711,0.00008078569,0.00002895611,0.0002199789,0.169141,0.000116999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518799,0.01929075,0.00003196914,0.009754449,0.0006220592,0.001072668,0.00005760644,0.00005739481,0.01723325],"genre_scores_gemma":[0.9882651,0.002752799,0.0001461369,0.004385188,0.0007887617,0.00007688681,0.00001856232,0.00002008035,0.003546487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3032557,"threshold_uncertainty_score":0.9993208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297615974164761,"score_gpt":0.2932668208430531,"score_spread":0.2802906611014054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}