{"id":"W4412095369","doi":"10.20944/preprints202507.0295.v1","title":"Integrative Mechanistic Studies Identify Reticulon-3 as a Critical Modulator of Infectious Exosome-Driven Dengue Pathogenesis","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dengue fever; Pathogenesis; Exosome; Dengue virus; Mechanism (biology); Virology; Computational biology; Medicine; Biology; Microvesicles; Immunology; Genetics; Physics; microRNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000320382,0.0004198864,0.0002108316,0.0001248294,0.0001698044,0.0004077155,0.0002537748,0.0002902973,0.001288366],"category_scores_gemma":[0.00009477326,0.0001013187,0.0003110927,0.00006664988,0.0002730346,0.0002752295,0.000356147,0.000499687,0.0004063718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000469712,"about_ca_system_score_gemma":0.000225743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816998,"about_ca_topic_score_gemma":0.000328151,"domain_scores_codex":[0.9998882,0.00002369662,0.000007282068,0.00003054743,0.00002511975,0.00002514921],"domain_scores_gemma":[0.999941,0.000005356799,0.0000239093,0.000006449232,0.000008190515,0.00001501452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000232608,0.0000273301,0.0005647229,0.00006450353,0.00001163937,0.0001420214,0.00001891543,0.0001817792,0.9955609,0.0008683021,0.0001181078,0.00220914],"study_design_scores_gemma":[0.00006995889,0.0006369101,0.0241721,0.0000378881,0.00006366435,0.001226048,0.0001500998,0.006862577,0.9513994,0.001058041,0.01430413,0.00001925601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769025,0.006320503,0.01118612,0.0005722509,0.00009391114,0.00006093334,0.0007556292,0.0001823744,0.00392588],"genre_scores_gemma":[0.9933702,0.001856831,0.002481875,0.0001196045,0.00001351395,0.00002541704,0.0004159571,0.00001758885,0.001699081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288366,"threshold_uncertainty_score":0.004309952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0833036727515982,"score_gpt":0.4213353679052195,"score_spread":0.3380316951536213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}