{"id":"W4412095484","doi":"10.1186/s13148-025-01893-1","title":"Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort","year":2025,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement; Université Laval; Quebec - Clinical Research Organization in Cancer","funders":"Institut Gustave-Roussy; Mutuelle Générale de l'Education Nationale; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Epigenome; DNA methylation; Human genetics; Alcohol consumption; Methylation; Cohort study; Cohort; Medicine; Biology; Genetics; Internal medicine; DNA; Alcohol; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001575833,0.000350614,0.0004187346,0.0006864733,0.0006102721,0.0005653228,0.0004007316,0.0006047976,0.001299196],"category_scores_gemma":[0.00140979,0.0002238859,0.0007617405,0.001048222,0.0002769653,0.0002228764,0.000407934,0.000355543,0.0001331172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001274178,"about_ca_system_score_gemma":0.0007809938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1509411,"about_ca_topic_score_gemma":0.1661772,"domain_scores_codex":[0.9993234,0.000229577,0.00002728134,0.0001977881,0.0001026416,0.0001193695],"domain_scores_gemma":[0.9994226,0.0001387813,0.0001370459,0.0000960926,0.0001098389,0.00009572109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000426406,0.00003713468,0.9938023,0.0000154603,0.0004542065,0.0002166949,0.0001627602,0.0001473892,0.001174342,0.00007284206,0.0003647637,0.00312566],"study_design_scores_gemma":[0.00001667369,0.00004250969,0.9989194,0.000005038163,0.00007885787,0.0001340515,0.00004731736,0.0001896138,0.00006621899,0.00002211798,0.0004737934,0.000004539187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975705,0.0006382495,0.0003507975,0.0001027796,0.000004709158,0.0000118242,0.0009568007,0.00000908282,0.0003552155],"genre_scores_gemma":[0.998212,0.0002665833,0.0003326963,0.00006625255,0.00000634071,0.00001788586,0.0007076684,0.000004258868,0.0003863875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1509411,"threshold_uncertainty_score":0.3001251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0420633297703761,"score_gpt":0.374484933585807,"score_spread":0.3324216038154309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}