{"id":"W4412098527","doi":"10.1111/boc.70024","title":"The Nuclear Envelope Proteins Esc1 and Mps3 Differentially Impact Sterol Gradients in Budding Yeast","year":2025,"lang":"en","type":"article","venue":"Biology of the Cell","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Biology; Budding yeast; Envelope (radar); Yeast; Sterol; Saccharomyces cerevisiae; Cell biology; Budding; Nuclear pore; Biochemistry; Aerospace engineering; Engineering; Cholesterol; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438719,0.0001147019,0.0001183617,0.00001887127,0.0001093563,0.00001178165,0.0003387893,0.0001574553,0.000004458273],"category_scores_gemma":[0.00006130795,0.00006244013,0.00007395889,0.00005810445,0.0002015194,0.000001309088,0.0002473785,0.00008239548,0.000001080476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009305028,"about_ca_system_score_gemma":0.00003593532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003130383,"about_ca_topic_score_gemma":0.00003821951,"domain_scores_codex":[0.9993404,0.0000904164,0.0001514204,0.0002003656,0.00003264193,0.0001847224],"domain_scores_gemma":[0.9996054,0.00002210796,0.00007885436,0.000252927,0.00001636624,0.00002440535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127285,0.0000400808,0.01809512,0.00001938494,0.00003861548,2.943042e-7,0.00001555604,8.324478e-7,0.9804355,0.00003814815,0.000233137,0.000956048],"study_design_scores_gemma":[0.0003170482,0.00007118753,0.03182462,0.00003381213,0.00001484174,0.000003586888,0.00003756575,0.00001404601,0.9612343,0.00009731678,0.006268671,0.00008300896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979125,0.0005116562,0.000007067597,0.0002605899,0.0000991998,0.0001613154,0.00004067544,0.000003264474,0.001003781],"genre_scores_gemma":[0.9988368,0.0002165827,0.00003312061,0.00005925354,0.00002739974,0.00000580648,0.00001353127,0.000005152599,0.0008023446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01920119,"threshold_uncertainty_score":0.2546234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004413407681572627,"score_gpt":0.212758824626993,"score_spread":0.2083454169454204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}