{"id":"W4412107782","doi":"10.1016/j.ebiom.2025.105830","title":"GWAS meta-analysis identifies five susceptibility loci for endometrial cancer","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Calgary","funders":"Estonian Research Competency Council; Cancer Council Victoria; European Research Council; Medical Research Council; Canadian Institutes of Health Research; Medizinischen Hochschule Hannover; Genome Canada; University of Melbourne; VicHealth; National Cancer Institute; Seventh Framework Programme; Eesti Teadusagentuur; National Health and Medical Research Council; Australian Institute of Health and Welfare, Australian Government; Cancer Research UK; Australian Government; Centers for Disease Control and Prevention; Nella and Leon Benoziyo Center for Neurological Diseases, Weizmann Institute of Science; QIMR Berghofer Medical Research Institute; Wellcome Trust; Wilhelm Sander-Stiftung; National Institutes of Health; Ovarian Cancer Research Fund","keywords":"Endometrial cancer; Genome-wide association study; Biology; Candidate gene; Oncology; Locus (genetics); Genetics; Cancer; Single-nucleotide polymorphism; Internal medicine; Cancer research; Gene; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009393744,0.0001480341,0.0007063606,0.0002416559,0.000105516,0.000009652678,0.0001742428,0.0001671482,0.0003526146],"category_scores_gemma":[0.001105,0.0001126933,0.0007583536,0.0006666923,0.0001392315,0.000001600196,0.00007808254,0.00005588021,0.000002793846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003050257,"about_ca_system_score_gemma":0.00008653497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004558975,"about_ca_topic_score_gemma":0.0009827744,"domain_scores_codex":[0.9987022,0.0001076554,0.0004015392,0.00043556,0.00009981312,0.0002531814],"domain_scores_gemma":[0.9990007,0.0001760489,0.0001454023,0.0003967737,0.0002261602,0.00005496027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0004654051,0.0002778866,0.06734729,0.0001116895,0.3182409,0.00000173785,0.0002036828,0.001071245,0.1583667,0.0002926943,0.4504257,0.003195077],"study_design_scores_gemma":[0.008081803,0.001264139,0.1322692,0.00000890994,0.4033184,0.000002032907,0.0009791121,0.001109905,0.0565182,0.005483766,0.3899992,0.0009652445],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8293592,0.02954427,0.1165464,0.01868238,0.001726135,0.001484794,0.0008986461,0.00004281726,0.00171542],"genre_scores_gemma":[0.977008,0.0002445514,0.001073278,0.001087308,0.0003880518,0.0002222228,0.0006708577,0.000007423466,0.01929828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1476489,"threshold_uncertainty_score":0.45955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338116496719088,"score_gpt":0.367838423867174,"score_spread":0.3244572588999831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}