{"id":"W4412116492","doi":"10.1002/acn3.70111","title":"Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"F. Hoffmann-La Roche","keywords":"Ocrelizumab; Medicine; Expanded Disability Status Scale; Multiple sclerosis; Internal medicine; Hazard ratio; Clinical endpoint; Oncology; Clinical trial; Confidence interval; Immunology; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02984186,0.001211972,0.001768543,0.00123803,0.000462479,0.001883321,0.0006402978,0.0007672101,0.001303553],"category_scores_gemma":[0.01870801,0.0002437315,0.002889115,0.001041959,0.0005549883,0.001313637,0.001486465,0.001649559,0.000195354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005261147,"about_ca_system_score_gemma":0.001088872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006759208,"about_ca_topic_score_gemma":0.001361031,"domain_scores_codex":[0.9871454,0.007807364,0.001254505,0.001390563,0.001985107,0.0004169347],"domain_scores_gemma":[0.9777785,0.009855266,0.008022145,0.00122937,0.001997156,0.001117554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1605533,0.002132434,0.653309,0.004470988,0.01838283,0.0001565456,0.0005179201,0.007209591,0.00691334,0.0006161775,0.001968091,0.1437696],"study_design_scores_gemma":[0.00498427,0.05195589,0.9132172,0.0005220906,0.008001534,0.0006720909,0.0001862764,0.009517973,0.006250596,0.000976077,0.003560131,0.0001558174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97852,0.01271375,0.002803616,0.0001825252,0.00008639047,0.0005461192,0.001680935,0.0000692679,0.003397348],"genre_scores_gemma":[0.996176,0.0007123582,0.00125948,0.00009781778,0.00007620876,0.0002926503,0.001106543,0.00001464234,0.0002642372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02984186,"threshold_uncertainty_score":0.1578207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2162473408675215,"score_gpt":0.4353104661622528,"score_spread":0.2190631252947313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}