{"id":"W4412120939","doi":"10.1021/acssynbio.5c00096","title":"Sequencing of a Dairy Isolate Unlocks <i>Kluyveromyces marxianus</i> as a Host for Lactose Valorization","year":2025,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agropur cooperative; Concordia University","funders":"Concordia University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Genome Canada","keywords":"Kluyveromyces marxianus; Lactose; Host (biology); Kluyveromyces; Biology; Food science; Biotechnology; Microbiology; Yeast; Biochemistry; Saccharomyces cerevisiae; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003410187,0.000683378,0.0005710244,0.0005189162,0.0004564669,0.0008163887,0.0004160515,0.0005017952,0.0007406482],"category_scores_gemma":[0.0008356773,0.0001910755,0.0008770557,0.001428463,0.0002259291,0.0003299947,0.0007422228,0.0006287409,0.001093475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005304385,"about_ca_system_score_gemma":0.0009593245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005542576,"about_ca_topic_score_gemma":0.004784175,"domain_scores_codex":[0.9995864,0.00003603218,0.0000678161,0.0001043856,0.0001300346,0.00007535212],"domain_scores_gemma":[0.9994903,0.00009602711,0.0001407186,0.00005828328,0.0001313335,0.00008338685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004437583,0.00006247968,0.006011693,0.0003846152,0.00004271631,0.001399928,0.0005217091,0.0003969249,0.9733801,0.0002619078,0.0005714372,0.01652273],"study_design_scores_gemma":[0.00009019562,0.0005175048,0.1389021,0.0003255949,0.0006302818,0.004578225,0.002609878,0.003142738,0.771794,0.0005911005,0.07666232,0.0001560223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569643,0.001727099,0.01179692,0.0003682362,0.0001601616,0.0002486322,0.02392357,0.0004713995,0.004339691],"genre_scores_gemma":[0.9159396,0.002041594,0.02347794,0.000358573,0.00005393081,0.0001710921,0.05288041,0.0004998654,0.004576971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005542576,"threshold_uncertainty_score":0.0110206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01565310010260932,"score_gpt":0.2431940766646779,"score_spread":0.2275409765620686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}