{"id":"W4412124121","doi":"10.1021/acs.jmedchem.5c01170","title":"Precision-Oriented Theophylline-Platinum(IV) Prodrugs: Eliciting Synthetic Lethality in BRCA1-Deficient Ovarian Cancer with Enhanced Efficacy and Reduced Toxicity <i>In Vitro</i> and <i>In Vivo</i>","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Olaparib; Synthetic lethality; Cisplatin; Prodrug; Chemistry; In vivo; Theophylline; Cancer research; Ovarian cancer; Pharmacology; DNA damage; DNA repair; PARP inhibitor; Poly ADP ribose polymerase; Cancer; Chemotherapy; Medicine; Internal medicine; Biology; Biochemistry; DNA; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007649873,0.0002129901,0.0001696421,0.0001211541,0.00006168347,0.0001598232,0.0001620792,0.0002065205,0.0006761605],"category_scores_gemma":[0.0001012555,0.00009275947,0.000143369,0.00008770625,0.00008730563,0.0001766196,0.0001276666,0.0003193869,0.0001590195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542092,"about_ca_system_score_gemma":0.00011283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000207266,"about_ca_topic_score_gemma":0.0003944946,"domain_scores_codex":[0.9999533,0.000007146911,0.000005617244,0.00001307626,0.000009562494,0.00001131821],"domain_scores_gemma":[0.9999715,0.00000287924,0.00001188526,0.000003330772,0.0000044115,0.000005927186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002308329,0.0000896376,0.000182709,0.0001648622,0.000009927614,0.0001350301,0.00002308704,0.0008267838,0.9857017,0.0004485155,0.0003128275,0.01187425],"study_design_scores_gemma":[0.00006598074,0.001469382,0.0006773175,0.000009502844,0.00001776393,0.0003806465,0.00001006728,0.001187298,0.9897661,0.00008766992,0.006321243,0.000006946756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847973,0.003328445,0.006972939,0.0001356419,0.00005927342,0.00009995882,0.0003472567,0.0001412469,0.004117953],"genre_scores_gemma":[0.9929973,0.001340485,0.0032726,0.00005942193,0.000006827949,0.00004403352,0.0002557809,0.00001271388,0.002010872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006761605,"threshold_uncertainty_score":0.002261937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316967641941048,"score_gpt":0.2748016075001646,"score_spread":0.2616319310807541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}