{"id":"W4412125701","doi":"10.1200/po-25-00200","title":"Risk Assessment With Ultra-Low-Pass Whole-Genome Sequencing of Cell-Free DNA for Large B-Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"DNA; Genome; Cell-free fetal DNA; DNA sequencing; Computational biology; Whole genome sequencing; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008449415,0.0004943511,0.0003069455,0.001294945,0.0001648611,0.0008292814,0.0003398178,0.0003826974,0.0006805349],"category_scores_gemma":[0.00211582,0.0001775871,0.0002300667,0.0005756631,0.0002540903,0.0003042035,0.0007120014,0.0003645143,0.0002207337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166859,"about_ca_system_score_gemma":0.0002130872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104759,"about_ca_topic_score_gemma":0.00222341,"domain_scores_codex":[0.9994809,0.0001774958,0.00002978773,0.0001601812,0.0001076915,0.00004392628],"domain_scores_gemma":[0.999189,0.00026762,0.0002995527,0.0001129064,0.00008047365,0.00005039318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00077847,0.00006851205,0.7053476,0.0002262499,0.0002927572,0.00043642,0.0002657501,0.00443598,0.1802172,0.0005369778,0.0008017182,0.1065923],"study_design_scores_gemma":[0.00005178094,0.0007362114,0.832489,0.0001175205,0.0005074018,0.004406011,0.000396111,0.03988731,0.1093255,0.00335286,0.008672813,0.00005765975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.948428,0.003713066,0.04448987,0.0001914703,0.00001743831,0.000076738,0.001581332,0.0003194838,0.001182625],"genre_scores_gemma":[0.9837421,0.000551669,0.01395061,0.0001196725,0.00002172152,0.00003688019,0.001060102,0.00003094227,0.0004863703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294945,"threshold_uncertainty_score":0.004468501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223702684515305,"score_gpt":0.3058445890225691,"score_spread":0.293607562177416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}