{"id":"W4412147782","doi":"10.20944/preprints202507.0638.v1","title":"The CB₂ Receptor in Immune Regulation and Disease: Genetic Architecture, Epigenetic Control, and Emerging Therapeutic Strategies","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval","keywords":"Epigenetics; Immune system; Disease; Genetic architecture; Epigenesis; Biology; Computational biology; Medicine; Genetics; DNA methylation; Gene; Phenotype; Gene expression; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169017,0.0003067825,0.000545678,0.0003338365,0.0002620584,0.0007667124,0.0003279865,0.0007595993,0.002190969],"category_scores_gemma":[0.0002866693,0.0001422442,0.0003031323,0.0002916647,0.00105057,0.000660539,0.000533889,0.001404523,0.00063578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006753883,"about_ca_system_score_gemma":0.0006629488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005296342,"about_ca_topic_score_gemma":0.0006554298,"domain_scores_codex":[0.9998742,0.00002841142,0.000006177774,0.00002765203,0.00003931863,0.00002418616],"domain_scores_gemma":[0.9999263,0.00002287037,0.00001108925,0.000009780133,0.00001392196,0.00001593293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007517865,0.0001068102,0.002175029,0.003467081,0.0001882977,0.001807264,0.0005644853,0.001781768,0.1613244,0.1634514,0.02768611,0.6366955],"study_design_scores_gemma":[0.000101962,0.0003781376,0.00730422,0.0008917909,0.0002061116,0.004259153,0.000413981,0.001273223,0.0490199,0.1130965,0.8229711,0.00008396397],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02816498,0.9073153,0.02074857,0.02171072,0.002360839,0.00003850096,0.0003510074,0.0003650402,0.01894502],"genre_scores_gemma":[0.2033959,0.7627381,0.009457824,0.004321949,0.002631848,0.00008859643,0.0004443726,0.00009668642,0.01682479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002190969,"threshold_uncertainty_score":0.007329524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02683390374608853,"score_gpt":0.3106963309576699,"score_spread":0.2838624272115813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}