{"id":"W4412162065","doi":"10.1182/blood.2025028865","title":"Silence of the myeloma clones: GPRC5D epigenetic regulation","year":2025,"lang":"en","type":"letter","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Multiple myeloma; Epigenetics; Biology; Cancer research; Medicine; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010685,0.0004313539,0.0006281272,0.0003386251,0.001039736,0.001302644,0.0007085112,0.01069106,0.002099738],"category_scores_gemma":[0.004210109,0.000295833,0.0005750075,0.0002241606,0.000814414,0.0007476674,0.0005729765,0.01174664,0.002596236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001475786,"about_ca_system_score_gemma":0.0004818619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529009,"about_ca_topic_score_gemma":0.001020971,"domain_scores_codex":[0.9990351,0.0002207116,0.000100827,0.0001150733,0.000384094,0.0001441662],"domain_scores_gemma":[0.9986313,0.0007443023,0.000150708,0.00006965786,0.000233908,0.0001700761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003921948,0.0001873697,0.002346858,0.0001429842,0.00005707509,0.01348776,0.0001664686,0.0001641086,0.01077958,0.004022823,0.9053542,0.06289854],"study_design_scores_gemma":[0.0003928758,0.000473967,0.003275353,0.0001082331,0.0001139498,0.01913622,0.000230612,0.001706696,0.01137749,0.006760396,0.956367,0.0000572247],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006416664,0.00812444,0.001511917,0.916237,0.06167451,0.00005541771,0.0001324762,0.0002065276,0.005641037],"genre_scores_gemma":[0.04388338,0.007076313,0.001202235,0.8181288,0.1136565,0.00009697022,0.0001308528,0.00006695819,0.01575799],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01069106,"threshold_uncertainty_score":0.01070762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850332639500282,"score_gpt":0.2751283451659038,"score_spread":0.2566250187709009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}