{"id":"W4412166630","doi":"10.1017/cjn.2025.10253","title":"P.094 A phase 1, multicenter, randomized, placebo-controlled, multiple ascending dose study to evaluate the safety and tolerability of AMX0114 in ALS (LUMINA)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Placebo; Medicine; Internal medicine; Adverse effect; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002048706,0.001794904,0.001859177,0.0004274857,0.000617869,0.001086874,0.0009609546,0.001972611,0.008732352],"category_scores_gemma":[0.001117612,0.00063286,0.0009152191,0.0003053169,0.00104122,0.0009723211,0.0003311829,0.003197216,0.0014823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006386194,"about_ca_system_score_gemma":0.001700467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004924756,"about_ca_topic_score_gemma":0.001216584,"domain_scores_codex":[0.9995286,0.0002343304,0.0000235993,0.00009481321,0.0000509705,0.00006766515],"domain_scores_gemma":[0.9991838,0.0001734068,0.0001967261,0.00005192622,0.00008899152,0.000305112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8633565,0.05360857,0.002023848,0.001167327,0.001149963,0.0001813571,0.0001278504,0.0007437957,0.03191255,0.0004460068,0.004893792,0.04038841],"study_design_scores_gemma":[0.7606959,0.232266,0.002805988,0.0000333334,0.0002386309,0.00008170279,0.00002241585,0.0005599083,0.001373157,0.0001797529,0.001726486,0.00001659896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770544,0.003536919,0.001626702,0.001186938,0.0004233813,0.008754496,0.002406324,0.0004573676,0.004553408],"genre_scores_gemma":[0.9657538,0.002151502,0.005729999,0.002988859,0.0003425533,0.01022352,0.002717457,0.00006893688,0.01002343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008732352,"threshold_uncertainty_score":0.02921259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04008879058846694,"score_gpt":0.3547332367283317,"score_spread":0.3146444461398648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}