{"id":"W4412174371","doi":"10.1093/nar/gkaf665","title":"FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften; Muscular Dystrophy Association; European Commission; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; Deutsche Forschungsgemeinschaft; Minnesota Department of Agriculture","keywords":"Biology; Cleavage (geology); Cell biology; Mitochondrial DNA; Computational biology; Genetics; Gene; Paleontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588024,0.0005142547,0.0002352796,0.0001710624,0.0002378846,0.0003564529,0.0002373814,0.0002840504,0.0009530776],"category_scores_gemma":[0.0001600027,0.0001629975,0.0003161043,0.000112349,0.0002189509,0.0002399322,0.0002349814,0.0002568847,0.0004502136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006023366,"about_ca_system_score_gemma":0.0002335987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048035,"about_ca_topic_score_gemma":0.001740374,"domain_scores_codex":[0.9998908,0.00001064041,0.00001075445,0.00003725519,0.00002553728,0.00002508173],"domain_scores_gemma":[0.9998777,0.00003246402,0.00002777492,0.00001647393,0.00001461917,0.00003093355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494012,0.00001877312,0.0009060465,0.000096982,0.000006597254,0.0001143152,0.0000246251,0.0002101568,0.9956387,0.0002677138,0.00004171812,0.002524941],"study_design_scores_gemma":[0.000006741595,0.00009578728,0.003670332,0.000006074734,0.000006027609,0.000311685,0.00002226432,0.0009435968,0.9926469,0.00006114195,0.002224072,0.000005330671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884145,0.00125423,0.008443543,0.00004982559,0.00002593437,0.00003029092,0.0005480009,0.0001031349,0.001130429],"genre_scores_gemma":[0.9856484,0.0005560533,0.009240554,0.00005381918,0.000004179748,0.00002061748,0.001320621,0.00003351996,0.003122126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048035,"threshold_uncertainty_score":0.004370272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0334520972340789,"score_gpt":0.3679066631338037,"score_spread":0.3344545658997248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}