{"id":"W4412177470","doi":"10.1038/s41531-025-01061-5","title":"Faecal microbiota transplant in Parkinson’s disease: pilot study to establish safety & tolerability","year":2025,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Hospital Research Foundation","keywords":"Parkinson's disease; Tolerability; Medicine; Disease; Fecal bacteriotherapy; Gut flora; Intensive care medicine; Internal medicine; Adverse effect; Biology; Immunology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004486979,0.0004938189,0.0007372528,0.0003378403,0.0001749083,0.00006751966,0.0003679121,0.0001195413,0.0005384844],"category_scores_gemma":[0.0004605072,0.0004136892,0.0002438125,0.001130858,0.0001729466,0.0000987121,0.000141005,0.0007576942,0.000191361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996563,"about_ca_system_score_gemma":0.0003834376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001588269,"about_ca_topic_score_gemma":0.0004455567,"domain_scores_codex":[0.9961516,0.0004550441,0.0008388827,0.001320136,0.0004703433,0.0007640441],"domain_scores_gemma":[0.9971811,0.0002081982,0.00007147182,0.001037063,0.0000962234,0.001405929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02797233,0.01703132,0.945384,0.0002812542,0.0001136959,0.0008497385,0.0003342081,0.000300949,0.000947979,0.00007881893,0.004617339,0.002088411],"study_design_scores_gemma":[0.004381435,0.0007173193,0.8366895,0.0002109248,0.0003296529,0.000002290152,0.00007833978,0.0001172524,0.00001388546,0.0001864686,0.156931,0.0003419468],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828838,0.001304788,0.0001847035,0.01036028,0.0004365368,0.002952137,0.0003175648,0.0002414074,0.001318839],"genre_scores_gemma":[0.9912495,0.0003783202,0.00008257016,0.006719192,0.00005906911,0.0001794998,0.0001404378,0.00004015934,0.001151273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1523137,"threshold_uncertainty_score":0.9998315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02394627995664055,"score_gpt":0.2873164558823963,"score_spread":0.2633701759257557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}