{"id":"W4412177649","doi":"10.1038/s41388-025-03487-w","title":"The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis","year":2025,"lang":"en","type":"article","venue":"Oncogene","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Waterloo; Toronto Rehabilitation Institute; University Health Network","funders":"","keywords":"Biology; Skeletal muscle; Homeostasis; Suppressor; Endocrinology; Carcinogenesis; Internal medicine; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791947,0.0004955144,0.00030005,0.0009751479,0.0002955232,0.0005075374,0.0004221862,0.0005101351,0.001087116],"category_scores_gemma":[0.0002853035,0.0005033173,0.0002143547,0.0003161176,0.0006163183,0.0004190685,0.0004069028,0.00118882,0.0006633328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004494538,"about_ca_system_score_gemma":0.0003025638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007002328,"about_ca_topic_score_gemma":0.001281949,"domain_scores_codex":[0.9996938,0.00003075304,0.00002603438,0.00005896747,0.0001158874,0.00007478266],"domain_scores_gemma":[0.9992568,0.00007244167,0.0003452552,0.00006313734,0.00005220351,0.0002102223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006716178,0.000006455544,0.0001382894,0.000008931841,0.000001917934,0.00005007885,0.000005997566,0.00003513541,0.9989562,0.0001722706,0.0000182737,0.0005392621],"study_design_scores_gemma":[0.00002705248,0.0001315014,0.006602375,0.000006707284,0.00001537167,0.0006395455,0.00003823778,0.000946129,0.9891406,0.0001521791,0.002294761,0.000005636766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868268,0.002438729,0.007443327,0.0002292203,0.00003111513,0.00002442944,0.0007650572,0.0003745613,0.001866822],"genre_scores_gemma":[0.9898149,0.0005603106,0.004350809,0.00004642385,0.00001287247,0.00003044269,0.0008289329,0.0001728089,0.004182495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087116,"threshold_uncertainty_score":0.003636837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006650403412186891,"score_gpt":0.2555406915720461,"score_spread":0.2488902881598592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}