{"id":"W4412178048","doi":"10.1038/s41541-025-01209-7","title":"Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants","year":2025,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Immunogenicity; Neuraminidase; Nasal administration; Virology; Microbiology; Neuraminidase inhibitor; Influenza vaccine; Medicine; Adjuvant; Immunology; Biology; Vaccination; Immune system; Virus; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211535,0.0002156671,0.0001712736,0.00009619062,0.00007480034,0.0001388456,0.00009050217,0.0002067274,0.0004923102],"category_scores_gemma":[0.0002042325,0.00006296619,0.000118842,0.00005097186,0.000148118,0.0001649794,0.00009187799,0.000348646,0.0001211171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001346265,"about_ca_system_score_gemma":0.0001545563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003494846,"about_ca_topic_score_gemma":0.0002816431,"domain_scores_codex":[0.9998908,0.00002373572,0.000008770891,0.00001646808,0.00002995641,0.00003018448],"domain_scores_gemma":[0.9999301,0.00001496221,0.00001123414,0.00000891897,0.00001741013,0.0000173658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000253026,0.00009420815,0.0003766512,0.00002040196,0.000004060838,0.0000157155,0.00001141378,0.00005667525,0.9977277,0.00002081707,0.000008198957,0.001411177],"study_design_scores_gemma":[0.00005298357,0.006707062,0.01669739,0.0000103148,0.00005141224,0.0003320955,0.00004402801,0.001009265,0.9740471,0.00006309501,0.000981029,0.000004130816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986083,0.0005237459,0.0003844787,0.00001859889,0.00001035633,0.00001176661,0.00004024926,0.000006472051,0.0003960047],"genre_scores_gemma":[0.9986778,0.0002564632,0.000489599,0.00001824613,0.000007569769,0.00001186849,0.0001143453,0.000002550404,0.0004214849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004923102,"threshold_uncertainty_score":0.001646936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260876432003614,"score_gpt":0.3264118066909618,"score_spread":0.3003241634906004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}