{"id":"W4412181783","doi":"10.1101/2025.07.05.663058","title":"CRYO-CEST: Non-invasive imaging of cryoprotectants using chemical exchange saturation transfer","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lanthanide and Transition Metal Complexes","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"","keywords":"Cryoprotectant; Saturation (graph theory); Chemistry; Nuclear magnetic resonance; Analytical Chemistry (journal); Environmental chemistry; Physics; Cryopreservation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005945136,0.0004996691,0.0003053134,0.000372478,0.0002055471,0.0005620841,0.0004386548,0.0005154688,0.001868141],"category_scores_gemma":[0.0002807482,0.0002926569,0.0001739416,0.0002280981,0.0005859388,0.000571231,0.0003616602,0.0005720077,0.0006711288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127708,"about_ca_system_score_gemma":0.0002673938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005292042,"about_ca_topic_score_gemma":0.0007261964,"domain_scores_codex":[0.9998689,0.0000270238,0.000004232719,0.00003518429,0.00004533885,0.00001936811],"domain_scores_gemma":[0.9998704,0.00004134712,0.00002313765,0.00001866177,0.0000312754,0.00001523749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000490882,0.000004671335,0.00007613399,0.00003574112,0.00000369904,0.00004850918,0.00001851387,0.0000908681,0.9977894,0.0002834808,0.0001036954,0.001496126],"study_design_scores_gemma":[0.000005418255,0.00004021771,0.0003640816,0.000003322416,0.000004701251,0.0001527224,0.00001012617,0.001365082,0.9964429,0.0001006273,0.001506269,0.000004501402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7733263,0.005637605,0.210016,0.0009328633,0.00014208,0.000148073,0.0007140393,0.0009476034,0.008135458],"genre_scores_gemma":[0.9100421,0.003343319,0.0749319,0.0002667487,0.00005774024,0.0001204454,0.0005160052,0.0002447167,0.010477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868141,"threshold_uncertainty_score":0.006249487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971527712594525,"score_gpt":0.2347585404977947,"score_spread":0.2150432633718495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}