{"id":"W4412182009","doi":"10.1038/s42003-025-08425-w","title":"Fortilin deficiency induces anti-atherosclerotic phenotypes in macrophages and protects hypercholesterolemic mice against atherosclerosis","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; Houston Methodist Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Anschutz Medical Campus, University of Colorado; School of Medicine, Vanderbilt University; Chulalongkorn University; Department of Laboratory Medicine and Pathology, University of Washington; American Heart Association; University of Washington; McGill University; Vanderbilt-Ingram Cancer Center; University of Missouri; National Institutes of Health; U.S. Department of Health and Human Services; Vanderbilt University; Universiti Teknologi MARA; Houston Methodist Hospital","keywords":"Phenotype; Macrophage; Atherosclerotic cardiovascular disease; Arteriosclerosis; Immunology; Medicine; Chemistry; Biology; Internal medicine; In vitro; Genetics; Disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407647,0.0005077299,0.0004428076,0.0007741876,0.0002583991,0.000322982,0.0003043895,0.0006301546,0.001646707],"category_scores_gemma":[0.0001266845,0.00038494,0.0003870805,0.0002319649,0.0003704952,0.0002754613,0.0003057746,0.0008592616,0.0005749314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571491,"about_ca_system_score_gemma":0.0001993034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007461964,"about_ca_topic_score_gemma":0.001024658,"domain_scores_codex":[0.9996943,0.00004450489,0.00004790071,0.00006746848,0.00005436331,0.00009146924],"domain_scores_gemma":[0.9996567,0.00001994065,0.0001042305,0.00003533363,0.00002574185,0.0001580815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004679253,0.0000769766,0.0002670859,0.00003272469,0.00000815192,0.00008313041,0.00002627162,0.00002395505,0.9982027,0.00007107924,0.00003675906,0.0007032327],"study_design_scores_gemma":[0.0002104849,0.001637468,0.01907888,0.00003007772,0.0000847902,0.0008603162,0.0001628443,0.001157839,0.9734614,0.0001592895,0.003133791,0.00002283323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958662,0.0007918536,0.001509358,0.000149306,0.00003278178,0.00004045968,0.0005570494,0.0001463915,0.0009066607],"genre_scores_gemma":[0.9916301,0.0008881562,0.001877391,0.0001490648,0.00002213816,0.00009590057,0.0007960561,0.00005914481,0.004481941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646707,"threshold_uncertainty_score":0.00550878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1320747283731766,"score_gpt":0.4511430142166535,"score_spread":0.3190682858434769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}