{"id":"W4412183506","doi":"10.1101/2025.07.07.662807","title":"Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Fundação para a Ciência e a Tecnologia; Ministério da Ciência, Tecnologia e Ensino Superior; European Commission; European Federation of Pharmaceutical Industries and Associations","keywords":"Central nervous system; Neuroscience; Biology; Computer science; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122171,0.0004916054,0.0002426226,0.0004270141,0.0002565315,0.000497738,0.0003775857,0.000460321,0.001351491],"category_scores_gemma":[0.00007731026,0.0001701071,0.0004146073,0.0001532378,0.0003829439,0.0002252183,0.0003780876,0.0009126046,0.0005281901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003895127,"about_ca_system_score_gemma":0.0004325624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592363,"about_ca_topic_score_gemma":0.003391915,"domain_scores_codex":[0.9998042,0.00002027585,0.00001488595,0.0000425473,0.00008829333,0.00002981778],"domain_scores_gemma":[0.9998757,0.000016774,0.00003655832,0.00002327592,0.00001607464,0.00003155358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003482241,0.00002868399,0.0001873225,0.00003484028,0.000006329004,0.0001106594,0.00002780407,0.0003534906,0.9977384,0.0002606855,0.0001022697,0.00111473],"study_design_scores_gemma":[0.00001468603,0.0001987388,0.002642423,0.00001374503,0.00002526201,0.0004321194,0.00005102176,0.002776301,0.9886613,0.0001352091,0.005037654,0.00001155613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9419993,0.001895932,0.04658121,0.0002477346,0.0001465765,0.0001849482,0.002541782,0.0005677355,0.005834829],"genre_scores_gemma":[0.9570146,0.001029993,0.03141385,0.000118746,0.00001785873,0.0002482946,0.001750317,0.00009185437,0.008314428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001592363,"threshold_uncertainty_score":0.004521251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626414547632274,"score_gpt":0.2380249818061702,"score_spread":0.2217608363298475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}