{"id":"W4412185627","doi":"10.1002/ardp.70046","title":"Click Chemistry‐Aided Synthesis of Triazole‐Tethered Benzothiazoles as Novel Multifunctional Agents Against Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"King Khalid University","keywords":"Benzothiazole; Tacrine; Chemistry; Docking (animal); Acetylcholinesterase; Donepezil; Galantamine; Triazole; Small molecule; Click chemistry; Stereochemistry; Pharmacology; Biochemistry; Enzyme; Combinatorial chemistry; Dementia; Biology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661365,0.0004264533,0.0002569979,0.0002179862,0.000122512,0.0001509871,0.0003464755,0.000429904,0.001721247],"category_scores_gemma":[0.0001364311,0.0001634641,0.0002939762,0.0003174307,0.0001636862,0.0002384096,0.0002205344,0.0004136983,0.0005505324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002345586,"about_ca_system_score_gemma":0.0002379659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006630967,"about_ca_topic_score_gemma":0.001603127,"domain_scores_codex":[0.9999052,0.00001365952,0.000007897368,0.00001494721,0.00002073884,0.0000375432],"domain_scores_gemma":[0.9999558,0.000004508311,0.00001534851,0.00000378671,0.00000899621,0.00001164386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144448,0.00009981421,0.0001296791,0.0003128118,0.00002757916,0.0003948016,0.00006920835,0.0008609366,0.9897959,0.0008391751,0.0005030244,0.006852578],"study_design_scores_gemma":[0.0001295255,0.001742896,0.002091204,0.00002688666,0.00005003849,0.0005168898,0.0000377468,0.003836054,0.9792906,0.0001473609,0.01208825,0.0000423906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952993,0.009891892,0.02580136,0.0004022038,0.0001860636,0.0003130136,0.0007450723,0.0004767257,0.009190571],"genre_scores_gemma":[0.9847575,0.003979085,0.007336204,0.0001118666,0.00002305496,0.0001053675,0.0002436917,0.00001662298,0.003426516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721247,"threshold_uncertainty_score":0.005758107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04575763116343202,"score_gpt":0.3447174429169458,"score_spread":0.2989598117535138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}