{"id":"W4412187759","doi":"10.1002/mco2.70277","title":"Casein Kinase 2α Ablation Confers Protection Against Metabolic Dysfunction‐Associated Steatotic Liver Disease: Role of FUN14 Domain Containing 1‐Dependent Regulation of Mitophagy and Ferroptosis","year":2025,"lang":"en","type":"article","venue":"MedComm","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Guangzhou Municipal Science and Technology Project; Fudan University; National Natural Science Foundation of China","keywords":"Steatosis; Mitophagy; Endocrinology; Internal medicine; Lipotoxicity; Biology; Nonalcoholic fatty liver disease; Liver injury; MFN2; Fatty liver; Mitochondrion; Fibrosis; PINK1; Autophagy; mitochondrial fusion; Medicine; Mitochondrial DNA; Insulin resistance; Cell biology; Biochemistry; Apoptosis; Diabetes mellitus; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552507,0.0003992925,0.00035101,0.0003087888,0.0001276792,0.0002212009,0.0001452552,0.0002833293,0.001534631],"category_scores_gemma":[0.0001045132,0.0001485648,0.0003043544,0.0001128059,0.0003124987,0.0002042304,0.0002183126,0.0005084887,0.0002624394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115914,"about_ca_system_score_gemma":0.0001430865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003135934,"about_ca_topic_score_gemma":0.0004662803,"domain_scores_codex":[0.9998977,0.00001621115,0.00001212361,0.00002736734,0.00001683145,0.0000297529],"domain_scores_gemma":[0.9998425,0.00001079403,0.00005810521,0.00001218405,0.00001055063,0.0000658198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00113942,0.00004812375,0.0006595218,0.00005886935,0.00001418913,0.0000830846,0.00001182229,0.00006236877,0.996848,0.00005469761,0.00004649246,0.0009733543],"study_design_scores_gemma":[0.0001470599,0.0009384959,0.03839076,0.00002722218,0.00007504552,0.0009398914,0.0001182703,0.001624875,0.9545726,0.0001642896,0.002985428,0.00001612593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969817,0.0008572272,0.001085588,0.00008711889,0.0000318556,0.00001585641,0.0004855639,0.00005259654,0.000402366],"genre_scores_gemma":[0.9963142,0.0004608685,0.0007616545,0.00005060764,0.0000081667,0.00003249535,0.0005344875,0.00002003249,0.001817364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534631,"threshold_uncertainty_score":0.005133867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304534717649677,"score_gpt":0.2384205000857088,"score_spread":0.225375152909212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}