{"id":"W4412196260","doi":"10.1002/bit.70019","title":"Regulating Transport Preferences of Fucosylated Sugars: Revealing Transport Mechanisms via Sugar Efflux Transporter A Transformation Into a “Tight‐in, Tight‐out” Mode","year":2025,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Transporter; Lactose permease; Biochemistry; Efflux; Mutant; Lactose; Chemistry; Transmembrane domain; Membrane transport protein; Biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002759093,0.0002413128,0.0003212194,0.0004354237,0.0000754586,0.000006596361,0.0002038476,0.0007493285,0.00001105764],"category_scores_gemma":[0.00001064628,0.0002294916,0.000092539,0.0004029204,0.0001057682,0.00001956193,0.00001666385,0.0002894445,7.418741e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002113027,"about_ca_system_score_gemma":0.00005675731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431792,"about_ca_topic_score_gemma":0.0006998927,"domain_scores_codex":[0.9985409,0.00002534576,0.0005462749,0.0004129648,0.0001438261,0.0003306452],"domain_scores_gemma":[0.9995446,0.000009215692,0.00006826261,0.0002618095,0.00006280308,0.00005335042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001470224,0.00004869887,0.001046345,0.0003576629,0.00008240652,0.00000432733,0.0004217972,0.0006409692,0.9913862,0.00168157,0.000003257011,0.004179682],"study_design_scores_gemma":[0.0009667758,0.0001993366,0.002907503,0.0001970343,0.00003544995,0.000007709713,0.0001910102,0.0052257,0.9885866,0.0007894007,0.0006460334,0.000247456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8182461,0.0004890469,0.1800777,0.0005246358,0.0000744534,0.0003987117,0.00001812388,0.00006556406,0.0001056751],"genre_scores_gemma":[0.9951152,0.0003830979,0.004170557,0.00002460293,0.00001529818,0.00004416025,0.0001631728,0.00001773477,0.00006612622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1768691,"threshold_uncertainty_score":0.9358395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0064595514565717,"score_gpt":0.2422029331928462,"score_spread":0.2357433817362745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}