{"id":"W4412199393","doi":"10.1128/mbio.01106-25","title":"Reply to Sleutel and Remaut, <sup>“</sup> Structural insights into <i>Escherichia coli</i> CsgA amyloid fibril assembly revisited”","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Escherichia coli; Amyloid fibril; Amyloid (mycology); Chemistry; Biophysics; Biology; Biochemistry; Amyloid β; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008585551,0.00202623,0.002825507,0.001402487,0.003130659,0.005196983,0.004382249,0.02825274,0.005351341],"category_scores_gemma":[0.02736465,0.00127422,0.00183736,0.001130169,0.005966471,0.009514951,0.003681679,0.05789161,0.006912095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003068696,"about_ca_system_score_gemma":0.004435222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003755831,"about_ca_topic_score_gemma":0.004872529,"domain_scores_codex":[0.9959465,0.000955438,0.000532343,0.0008170428,0.00131543,0.0004332184],"domain_scores_gemma":[0.980736,0.0103108,0.001173845,0.0005868399,0.004867066,0.002325444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005198975,0.00001737603,0.0001201048,0.0001047669,0.00001353398,0.0001252328,0.00006747726,0.00003028738,0.00009741935,0.0008311069,0.9943189,0.004221855],"study_design_scores_gemma":[0.0000656222,0.00006439709,0.0007239338,0.0002997802,0.00003036057,0.0006566311,0.0004103539,0.0002106736,0.0005007515,0.005004419,0.9919389,0.0000942917],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001516032,0.008428578,0.0002390352,0.925543,0.06507958,0.00001422237,0.0001261261,0.00006702292,0.0003509242],"genre_scores_gemma":[0.001579821,0.005689561,0.0003715899,0.9184052,0.07158004,0.00004889413,0.00007467833,0.0000442354,0.002206093],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02825274,"threshold_uncertainty_score":0.04540533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353313905430947,"score_gpt":0.2956974198365828,"score_spread":0.2821642807822733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}