{"id":"W4412203102","doi":"10.3390/biom15070987","title":"High Glucose in Diabetic Hyperglycemia Perturbs Lymphocyte SERCA-Regulated Ca2+ Stores with Accompanying ER Stress and Signaling Dysfunction","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, Davis; National Institutes of Health; University of the Pacific","keywords":"SERCA; Endoplasmic reticulum; Internal medicine; Endocrinology; Unfolded protein response; Immune system; Lymphocyte; Biology; Signal transduction; Jurkat cells; NFAT; Diabetes mellitus; Receptor; T-cell receptor; Cell biology; T cell; Medicine; Immunology; ATPase; Calcineurin; Biochemistry; Enzyme; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453925,0.0002841441,0.0001985913,0.0002189839,0.0001527685,0.0003904918,0.0001508945,0.0002273857,0.001195224],"category_scores_gemma":[0.00006997292,0.0001168164,0.0001838173,0.0002764324,0.0002372647,0.0002047083,0.0001887294,0.0004074777,0.0001771268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228241,"about_ca_system_score_gemma":0.0001747337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007388206,"about_ca_topic_score_gemma":0.001092756,"domain_scores_codex":[0.9999143,0.00001407947,0.00001074806,0.00002107825,0.00001573205,0.00002407808],"domain_scores_gemma":[0.9999424,0.000007136753,0.00001940531,0.00000799155,0.000005025721,0.00001797085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008225989,0.00007375966,0.001020685,0.00004454112,0.00001071203,0.0001911522,0.00001893772,0.00005095378,0.99557,0.0001031209,0.00005067938,0.002042844],"study_design_scores_gemma":[0.00006457232,0.001228657,0.05123138,0.00001968105,0.0000652941,0.0009422409,0.0001993532,0.000870056,0.9417429,0.0002017678,0.003423871,0.0000102585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945893,0.002104952,0.001639207,0.00009882091,0.00003882799,0.00001781592,0.000259193,0.00003547971,0.001216295],"genre_scores_gemma":[0.9962273,0.001227483,0.0009033841,0.00006240202,0.00001103611,0.00002131822,0.000224258,0.00001026079,0.00131268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195224,"threshold_uncertainty_score":0.003998399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003773507492269559,"score_gpt":0.2093045712539327,"score_spread":0.2055310637616631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}