{"id":"W4412203102","doi":"10.3390/biom15070987","title":"High Glucose in Diabetic Hyperglycemia Perturbs Lymphocyte SERCA-Regulated Ca2+ Stores with Accompanying ER Stress and Signaling Dysfunction","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, Davis; National Institutes of Health; University of the Pacific","keywords":"SERCA; Endoplasmic reticulum; Internal medicine; Endocrinology; Unfolded protein response; Immune system; Lymphocyte; Biology; Signal transduction; Jurkat cells; NFAT; Diabetes mellitus; Receptor; T-cell receptor; Cell biology; T cell; Medicine; Immunology; ATPase; Calcineurin; Biochemistry; Enzyme; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006088912,0.0002387323,0.000206833,0.000122796,0.00009847944,0.00006804153,0.0001245332,0.0001439587,0.000008272778],"category_scores_gemma":[0.0000461386,0.0001986332,0.00004775672,0.000193253,0.0001687435,0.000008790347,0.0001038361,0.00006829567,0.000001638205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004817832,"about_ca_system_score_gemma":0.0001291626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526233,"about_ca_topic_score_gemma":0.000227199,"domain_scores_codex":[0.9988177,0.0000715918,0.0002084254,0.0004841291,0.0001266175,0.0002915218],"domain_scores_gemma":[0.9994736,0.00002397098,0.00006287271,0.0002762541,0.00006470633,0.0000985915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008613471,0.0001706752,0.04597367,0.0001793756,0.0001289387,0.00005199071,0.00006167665,0.001249453,0.9454969,0.0002320447,0.0001183149,0.005475637],"study_design_scores_gemma":[0.003857148,0.0001482442,0.06324259,0.0003638076,0.00008792135,0.00001128917,0.0003509723,0.0006810124,0.9304018,0.0000739923,0.0003867765,0.0003944674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938241,0.00523028,0.0003658598,0.0001101344,0.0001069827,0.0001889704,0.00003354167,0.00002588917,0.0001141966],"genre_scores_gemma":[0.9987379,0.0002873518,0.0003800475,0.0001641186,0.00004619961,0.00003710201,0.0001728286,0.00002298325,0.0001514532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01726891,"threshold_uncertainty_score":0.8100026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003773507492269559,"score_gpt":0.2093045712539327,"score_spread":0.2055310637616631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}