{"id":"W4412354954","doi":"10.1101/2025.07.10.25331321","title":"Genome-wide analyses of quantitative generalised anxiety symptom severity","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Child and Adolescent Psychosocial and Emotional Development","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institutes of Health; UK Dementia Research Institute; NordForsk; National Health and Medical Research Council; Tartu Ülikool; Scottish Funding Council; Wetenschappelijk Onderzoek- en Documentatiecentrum; Universitair Medisch Centrum Groningen; Ministerie van Volksgezondheid, Welzijn en Sport; ZonMw; NIHR BioResource; Rijksuniversiteit Groningen; European Science Foundation; Deutsche Forschungsgemeinschaft; Medical Research Council; Department of Health and Social Care; NHS Blood and Transplant; National Institute for Health and Care Research; King's College London; UK Research and Innovation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Accare; Jan Dekker Stichting; Maudsley Charity; Eesti Teadusagentuur; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Scottish Government","keywords":"Anxiety; Neuroticism; Genome-wide association study; Heritability; Depression (economics); Irritable bowel syndrome; SNP; Clinical psychology; Genetic association; Medicine; Psychiatry; Psychology; Genetics; Gene; Single-nucleotide polymorphism; Biology; Personality; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005967834,0.001523223,0.002389685,0.002026666,0.0005710566,0.001682992,0.0009624253,0.001076015,0.001942059],"category_scores_gemma":[0.007056615,0.0006465781,0.01084884,0.003459331,0.000408014,0.0004016144,0.0009340877,0.001068499,0.0001863435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004282313,"about_ca_system_score_gemma":0.0004808148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006872684,"about_ca_topic_score_gemma":0.008228677,"domain_scores_codex":[0.9955007,0.002268894,0.0003278643,0.001311605,0.0003814714,0.0002094589],"domain_scores_gemma":[0.9964858,0.002043345,0.0004938259,0.0006217297,0.0002253084,0.0001299439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.005109289,0.00005387545,0.4397392,0.00230676,0.5302487,0.0005507005,0.0001706396,0.002071512,0.003793099,0.0003661651,0.001495391,0.0140947],"study_design_scores_gemma":[0.0009716651,0.0006559387,0.6539036,0.0003048816,0.3354448,0.0007354093,0.0001428859,0.002191849,0.001200449,0.00120311,0.003193187,0.00005219422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8407999,0.1404122,0.00769646,0.001012186,0.0004006909,0.00009081438,0.007707365,0.0002720162,0.001608378],"genre_scores_gemma":[0.9890226,0.006538636,0.001801343,0.0002367438,0.0001019803,0.00006764464,0.001802545,0.0000496259,0.0003789438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006872684,"threshold_uncertainty_score":0.03156132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06677131402134304,"score_gpt":0.3647427997639401,"score_spread":0.2979714857425971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}