{"id":"W4412362193","doi":"10.1038/s41598-025-10933-y","title":"Hyperglycemia-induced mitochondrial abnormalities in autonomic neurons via the RAGE axis","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Rage (emotion); Mitochondrion; Neuroscience; Medicine; Endocrinology; Internal medicine; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006648771,0.0001135363,0.0001064541,0.000132157,0.0002565331,0.0001147006,0.0002613898,0.00007651271,0.00003936338],"category_scores_gemma":[0.000524198,0.00009061016,0.00006209673,0.0004122581,0.000234245,0.00001138563,0.0002075273,0.0001573231,0.00001260072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003829561,"about_ca_system_score_gemma":0.0004217397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005155336,"about_ca_topic_score_gemma":0.00009592434,"domain_scores_codex":[0.9983488,0.0001053739,0.0003516494,0.0006884942,0.0002008304,0.0003048317],"domain_scores_gemma":[0.9985349,0.00002448115,0.00009685272,0.001185954,0.0001128392,0.00004496525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003603171,0.00003229787,0.0008586042,0.000009891145,0.00001088701,0.00003135723,0.00007642007,0.0005312953,0.9860746,0.0001053338,0.008835323,0.003398004],"study_design_scores_gemma":[0.0002259022,0.00003297549,0.002348199,0.00001071657,0.000005406593,0.00007250714,0.00009460967,0.0001062459,0.627982,0.00271335,0.3662668,0.0001412746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857895,0.0003141042,0.0008404374,0.001123019,0.006838282,0.000436325,0.000002514313,0.00001914535,0.004636712],"genre_scores_gemma":[0.972319,0.00001286639,0.0002046584,0.0001092294,0.0001512135,0.00005841307,0.00006959656,0.00001047217,0.02706452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3580926,"threshold_uncertainty_score":0.3694975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329810982795812,"score_gpt":0.2861554106743267,"score_spread":0.2728573008463686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}