{"id":"W4412365342","doi":"10.1002/advs.202508907","title":"Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Messenger RNA; RNA; Biology; Gene expression; In vivo; Molecular biology; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000760596,0.00007713985,0.00008471537,0.00003217581,0.0001065289,0.00002159519,0.0001492291,0.00003042502,0.000002051927],"category_scores_gemma":[0.00005441019,0.00006748475,0.00001642255,0.0001316589,0.0005843209,0.00001730421,0.0003184987,0.00002558772,3.550244e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004883489,"about_ca_system_score_gemma":0.00002887609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001275485,"about_ca_topic_score_gemma":0.000006476551,"domain_scores_codex":[0.9993277,0.00001176402,0.000122977,0.0002623914,0.00009514562,0.0001800065],"domain_scores_gemma":[0.9996456,0.0000108119,0.00004388635,0.0001703368,0.0000804824,0.00004889425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003927848,0.00001647579,0.002842918,0.00001331471,0.000003169947,3.047961e-7,0.000127266,0.00005923699,0.9860651,0.00005597052,0.00002176188,0.01075521],"study_design_scores_gemma":[0.0001800351,0.0001629118,0.009227328,0.00003860846,0.000003208753,0.000001903155,0.0005236831,0.00007595533,0.9891585,0.0001104852,0.0004434087,0.00007395673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961024,0.003033063,0.0004340982,0.00004908672,0.0001176079,0.00005364461,0.000009956739,0.000004329864,0.000195836],"genre_scores_gemma":[0.9976162,0.001234976,0.0007163586,0.0001164826,0.00001333582,0.000004862222,0.000001590124,0.00000260695,0.0002936374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01068125,"threshold_uncertainty_score":0.2751948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006860086978951871,"score_gpt":0.2719149000270661,"score_spread":0.2650548130481142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}