{"id":"W4412365342","doi":"10.1002/advs.202508907","title":"Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Messenger RNA; RNA; Biology; Gene expression; In vivo; Molecular biology; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578987,0.0001991666,0.00009667328,0.00008028436,0.00007024073,0.000247472,0.0001138957,0.0001441607,0.0003143172],"category_scores_gemma":[0.0002320087,0.00008888746,0.00007169414,0.00007605496,0.0001688761,0.0001953535,0.00009112064,0.0002682948,0.0001268184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000373459,"about_ca_system_score_gemma":0.0002037034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008635371,"about_ca_topic_score_gemma":0.001211421,"domain_scores_codex":[0.9999118,0.00001333613,0.00000615608,0.00002847821,0.00002434698,0.00001588654],"domain_scores_gemma":[0.9999038,0.00003198616,0.00003200654,0.00000581195,0.00001883013,0.000007496059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004324004,0.000006041407,0.00009503774,0.00001484238,0.000001131554,0.000008165468,0.00001534481,0.0001432221,0.9986379,0.00005267678,0.000007937947,0.0009744861],"study_design_scores_gemma":[0.000001954081,0.00009725738,0.0003595554,0.000001151395,0.000003166421,0.00001143309,0.000006557868,0.0008625633,0.9983297,0.00001211026,0.0003126113,0.000001991833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921826,0.0006403142,0.005965711,0.000030036,0.000009227149,0.00001462085,0.00006529418,0.00004817357,0.001044046],"genre_scores_gemma":[0.9949773,0.0004328907,0.002893702,0.00001424579,0.000002385078,0.00002254789,0.0000625172,0.00001782688,0.001576517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008635371,"threshold_uncertainty_score":0.002709627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006860086978951871,"score_gpt":0.2719149000270661,"score_spread":0.2650548130481142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}