{"id":"W4412387662","doi":"10.1080/13696998.2025.2530862","title":"Cost-effectiveness analysis of pembrolizumab as an adjuvant treatment of early-stage non-small cell lung cancer following complete resection and platinum-based chemotherapy in Canada","year":2025,"lang":"en","type":"article","venue":"Journal of Medical Economics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Merck Canada Inc. (Canada)","funders":"","keywords":"Medicine; Pembrolizumab; Stage (stratigraphy); Chemotherapy; Oncology; Lung cancer; Adjuvant chemotherapy; Adjuvant; Cancer; Internal medicine; Resection; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002954321,0.0009423138,0.00151004,0.001235003,0.0006739313,0.001591824,0.001514863,0.0009206653,0.002286017],"category_scores_gemma":[0.01080488,0.0005495067,0.003975071,0.001796274,0.0006662352,0.0005692971,0.0009892988,0.001413409,0.00009605751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.09298358,"about_ca_system_score_gemma":0.06523328,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9466938,"about_ca_topic_score_gemma":0.9456381,"domain_scores_codex":[0.997875,0.0008687477,0.0001176394,0.0002114166,0.0004526957,0.0004745129],"domain_scores_gemma":[0.9967577,0.001085358,0.0005958561,0.00009215142,0.0007461834,0.0007227376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.08459325,0.002406495,0.1942925,0.007912696,0.02563866,0.0009608734,0.0003447483,0.5243151,0.002430327,0.01054951,0.01523668,0.1313191],"study_design_scores_gemma":[0.02451609,0.008993044,0.3362189,0.002835258,0.03172605,0.0007934382,0.0009507384,0.5743642,0.001945649,0.004537688,0.01267905,0.0004399275],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497473,0.02459807,0.001984251,0.004664712,0.0001475184,0.001170895,0.01149193,0.00008469836,0.006110691],"genre_scores_gemma":[0.9932213,0.002865071,0.0009354237,0.0003000132,0.00001773575,0.0001237941,0.001991755,0.000009040324,0.0005357714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09298358,"threshold_uncertainty_score":0.6746463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408850010101859,"score_gpt":0.3212812795561362,"score_spread":0.2971927794551176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}