{"id":"W4412389942","doi":"10.3390/ijms26146699","title":"A Novel Chemotherapy Combination to Enhance Proteotoxic Cell Death in Hepatocellular Carcinoma Experimental Models Without Killing Non-Cancer Cells","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"State of Florida; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Ixazomib; Cancer research; Cancer cell; Proteasome inhibitor; Programmed cell death; Biology; Cancer; Hepatocellular carcinoma; Apoptosis; Proteasome; Cell biology; Carfilzomib; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009697706,0.000358458,0.0004231413,0.0003876346,0.0001192874,0.0001674361,0.0001918933,0.000186504,0.001404673],"category_scores_gemma":[0.0000527856,0.00009885948,0.0002257478,0.0002699752,0.0001562397,0.000183745,0.0001270427,0.0004478624,0.0001874046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730841,"about_ca_system_score_gemma":0.0003323624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006981013,"about_ca_topic_score_gemma":0.00226221,"domain_scores_codex":[0.9999254,0.00001207986,0.000007814963,0.00001732154,0.00001991548,0.00001744643],"domain_scores_gemma":[0.9999661,0.000004126849,0.000008487875,0.000004893422,0.000004997022,0.00001141742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743023,0.000788309,0.0005642184,0.0003124587,0.000054841,0.0001364765,0.00003337428,0.0005089768,0.9721539,0.0003189345,0.0004817492,0.02290375],"study_design_scores_gemma":[0.0008034576,0.01185342,0.005869007,0.00002042599,0.0001531302,0.0008582175,0.00002995805,0.001326518,0.9647273,0.00007998524,0.01425848,0.0000201138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856705,0.005871817,0.004472405,0.000247832,0.0001465,0.0003407781,0.0004207053,0.0002362983,0.002593159],"genre_scores_gemma":[0.9881131,0.003487459,0.004313951,0.00008093405,0.00003089164,0.00020791,0.0006034628,0.0000159892,0.003146375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404673,"threshold_uncertainty_score":0.004699111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015905010530558,"score_gpt":0.313582414941916,"score_spread":0.297677404411358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}