{"id":"W4412391795","doi":"10.1016/j.jcjd.2025.06.008","title":"Blood Characteristics of Adults With Type 2 Diabetes and Response of Their Peripheral Blood Mononuclear Cells to Inhibitors of the NLRP3 Inflammasome and Caspase-1","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Universitätsspital Zürich; Novartis Institutes for BioMedical Research; Universität Basel; Staatssekretariat für Bildung, Forschung und Innovation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis","keywords":"Inflammasome; Peripheral blood mononuclear cell; Medicine; Immunology; Inflammation; Immune system; Type 2 diabetes; Innate immune system; NEFA; Ex vivo; Diabetes mellitus; Systemic inflammation; Internal medicine; In vivo; Endocrinology; Biology; Insulin; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505475,0.0002035152,0.0002622646,0.0003338938,0.0002397273,0.0002873449,0.00007781551,0.0003069352,0.002496331],"category_scores_gemma":[0.0006037235,0.00007158962,0.0001593039,0.0006212353,0.00007518574,0.0001526166,0.0001186036,0.0002949405,0.0003385033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117248,"about_ca_system_score_gemma":0.0001278257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294394,"about_ca_topic_score_gemma":0.00148697,"domain_scores_codex":[0.9998807,0.00001480339,0.00001499401,0.00004168781,0.00002687813,0.00002095264],"domain_scores_gemma":[0.9996995,0.00004168575,0.0001307798,0.00001411542,0.00003787644,0.00007615719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006861858,0.00009424811,0.9897166,0.00003416597,0.0000467336,0.0003095376,0.00006973014,0.00003341177,0.002868022,0.00002628898,0.0003630617,0.005752068],"study_design_scores_gemma":[0.00000899379,0.000181092,0.9984168,0.00000693791,0.00001946609,0.0007488556,0.00007818864,0.00003759429,0.0001170315,0.00001885639,0.0003640116,0.000002274897],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939553,0.001879381,0.0002240987,0.0001102551,0.00002691572,0.00001698695,0.001781291,0.000009655325,0.001996085],"genre_scores_gemma":[0.9969062,0.0006262247,0.0002176301,0.0001266491,0.00003689548,0.00003074154,0.001254268,0.000002787415,0.0007987838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496331,"threshold_uncertainty_score":0.008351088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001924383386131853,"score_gpt":0.1620910794000615,"score_spread":0.1601666960139296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}