{"id":"W4412392013","doi":"10.1016/j.pt.2025.06.008","title":"East Coast fever mRNA vaccines – sweetening the promise","year":2025,"lang":"en","type":"review","venue":"Trends in Parasitology","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Consortium of International Agricultural Research Centers; Canadian International Development Agency; Bill and Melinda Gates Foundation; United States Agency for International Development; U.S. Department of Agriculture; Department for International Development, UK Government; National Science Foundation","keywords":"Immune system; Biology; Virology; East Coast fever; Antigen; Immunity; Antibody; Immunology; Cytotoxic T cell; Pathogen; Acquired immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587511,0.0004569587,0.001297344,0.00009676117,0.0001743453,0.00005339176,0.0008815827,0.0003778144,0.0006758397],"category_scores_gemma":[0.0001248997,0.0001365191,0.0004827933,0.001404466,0.00009981715,0.00006015161,0.0002411835,0.0004229606,0.00009678963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004908014,"about_ca_system_score_gemma":0.00004901657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002484052,"about_ca_topic_score_gemma":0.004615954,"domain_scores_codex":[0.9976688,0.000485237,0.0005554341,0.0006276873,0.0001477259,0.0005151095],"domain_scores_gemma":[0.9987849,0.0006733785,0.0002581874,0.0001638238,0.00003615484,0.00008358376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001501188,0.00007497418,0.004635158,0.0004442759,0.00006488096,0.00006067018,0.00001623723,3.151384e-7,0.000004861874,0.0001577299,0.004798403,0.9897275],"study_design_scores_gemma":[0.0001125093,0.00009166125,0.1038521,0.001745873,0.0004033719,0.00007005694,0.00004217539,0.000002207429,4.809523e-7,0.00005673822,0.8932733,0.0003495181],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002591373,0.993783,1.116422e-7,0.0005765629,0.0003780767,0.0003200043,0.0001254039,0.00009485548,0.002130641],"genre_scores_gemma":[0.004660212,0.9912841,0.00001278744,0.0001463794,0.0005034647,0.0002899863,0.0003491237,0.000003648228,0.002750265],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.989378,"threshold_uncertainty_score":0.7399971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05961202617803094,"score_gpt":0.3555836882560027,"score_spread":0.2959716620779717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}