{"id":"W4412392013","doi":"10.1016/j.pt.2025.06.008","title":"East Coast fever mRNA vaccines – sweetening the promise","year":2025,"lang":"en","type":"review","venue":"Trends in Parasitology","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Consortium of International Agricultural Research Centers; Canadian International Development Agency; Bill and Melinda Gates Foundation; United States Agency for International Development; U.S. Department of Agriculture; Department for International Development, UK Government; National Science Foundation","keywords":"Immune system; Biology; Virology; East Coast fever; Antigen; Immunity; Antibody; Immunology; Cytotoxic T cell; Pathogen; Acquired immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001072773,0.0007740441,0.001376819,0.001084741,0.0001673089,0.001231719,0.0007009069,0.001428183,0.00419797],"category_scores_gemma":[0.001028328,0.000246644,0.00044563,0.001084535,0.0006901608,0.0018013,0.0007437245,0.003014922,0.00176605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000577374,"about_ca_system_score_gemma":0.00129761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022582,"about_ca_topic_score_gemma":0.002214263,"domain_scores_codex":[0.9998083,0.00004075954,0.00002212191,0.00003368451,0.00006338255,0.00003177043],"domain_scores_gemma":[0.9994905,0.0002870069,0.00005555769,0.00001428239,0.00009617992,0.00005647384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001508327,0.0000586053,0.00009969288,0.007810353,0.0000641951,0.0001007331,0.00003673755,0.0002373988,0.002468958,0.004603278,0.03191641,0.9524528],"study_design_scores_gemma":[0.00004614154,0.0001385909,0.0004974052,0.003063982,0.0001034324,0.0004533325,0.00004583607,0.00007388201,0.0004803894,0.002060541,0.993022,0.00001447428],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009122401,0.9985995,0.00009616192,0.0003831602,0.0002767791,0.000002759317,0.00001464309,0.000006256615,0.0005295651],"genre_scores_gemma":[0.0007531846,0.9977168,0.0002047887,0.0005531909,0.0002378181,0.000005992188,0.00003971031,0.000001875726,0.0004866869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00419797,"threshold_uncertainty_score":0.01404363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05961202617803094,"score_gpt":0.3555836882560027,"score_spread":0.2959716620779717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}