{"id":"W4412392651","doi":"10.1016/j.jbc.2025.110473","title":"TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Erasmus+; Medical Research Council; Directorate for Biological Sciences; Biotechnology and Biological Sciences Research Council; Cardiff University; European Regional Development Fund; King's College London; Llywodraeth Cymru; British Heart Foundation; Saudi Arabia Cultural Bureau in London; Wellcome Trust","keywords":"Ectodomain; Cell biology; T-cell receptor; Biology; Jurkat cells; Phosphorylation; Cytoplasm; T cell; Receptor; Biochemistry; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Biochemistry paper on regulated intramembrane proteolysis of L-selectin in T cells; the object is cell signalling."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study investigates molecular mechanisms of L-selectin processing in T cells."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Cell/molecular immunology of L-selectin proteolysis after TCR activation."}}}