{"id":"W4412392819","doi":"10.1016/j.ebiom.2025.105839","title":"Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review","year":2025,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University; Ted Rogers Centre for Heart Research; Canada Research Chairs","funders":"Canadian Institutes of Health Research; University Health Network; Heart and Stroke Foundation of Canada","keywords":"Biology; NRF1; Bioinformatics; Transcriptome; Epigenomics; Systems biology; TFAM; Genetics; Mitochondrial DNA; Gene; Transcription factor; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00592983,0.001405414,0.005783525,0.01429744,0.0005615141,0.001973007,0.001549977,0.001268037,0.004091954],"category_scores_gemma":[0.01889938,0.0006742541,0.006057608,0.01338323,0.0007667241,0.001954595,0.001528026,0.0007879358,0.0003575399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002924419,"about_ca_system_score_gemma":0.009151367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006553325,"about_ca_topic_score_gemma":0.01950789,"domain_scores_codex":[0.9964918,0.001223896,0.00130524,0.0003406981,0.0005171404,0.0001211865],"domain_scores_gemma":[0.9807435,0.01439097,0.002690013,0.0003133485,0.001594947,0.0002671872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001641905,0.00001605852,0.001612556,0.9156951,0.009729125,0.0001378503,0.0001909994,0.0001574055,0.0003050431,0.0003217921,0.001676445,0.06999339],"study_design_scores_gemma":[0.000208557,0.0002860723,0.009919195,0.8788291,0.07369749,0.0006845579,0.0004155669,0.000163599,0.0003051267,0.0006759716,0.034755,0.00005973196],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006705826,0.9984413,0.000133977,0.0001768253,0.00004319456,0.00007711478,0.0003166766,0.000004889885,0.0001354324],"genre_scores_gemma":[0.01044224,0.9879156,0.0006972234,0.0002644109,0.00004589303,0.0002354814,0.0003347788,0.000003642671,0.00006065938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01429744,"threshold_uncertainty_score":0.03136033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05984388517829087,"score_gpt":0.3552227659436176,"score_spread":0.2953788807653267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}