{"id":"W4412392913","doi":"10.1016/j.etap.2025.104757","title":"Effects of bisphenol A alternatives (BPS and BPAF) on zebrafish (Danio rerio) spermatogenesis ex vivo: meiosis damage and transcriptional deregulation of genes related to spermatogenic processes and epigenetic regulation","year":2025,"lang":"en","type":"article","venue":"Environmental Toxicology and Pharmacology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Ex vivo; Zebrafish; Biology; Epigenetics; Spermatogenesis; Cell biology; Danio; Regulation of gene expression; Downregulation and upregulation; In vivo; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111921,0.000190842,0.0002972221,0.00008941878,0.0001132643,0.000006678383,0.00007590403,0.0001192048,0.0003314426],"category_scores_gemma":[0.00002287999,0.0001781012,0.00002650911,0.0001087793,0.0006794306,0.00009869906,0.0001497505,0.00008478884,0.000002248752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003134701,"about_ca_system_score_gemma":0.000006429475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000191388,"about_ca_topic_score_gemma":0.000009569629,"domain_scores_codex":[0.9988726,0.0001454637,0.0002954908,0.0003987323,0.0000997683,0.0001878938],"domain_scores_gemma":[0.9993605,0.0003521456,0.0001191884,0.00007275597,0.000003746849,0.00009163973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174242,0.0001916203,0.0624651,0.0002255643,0.00008417641,0.000003902135,0.0005395475,0.0001656613,0.9318848,0.00009052251,0.00007971853,0.004095097],"study_design_scores_gemma":[0.000932192,0.0002264175,0.3858277,0.00002978741,0.0001078064,0.00001692543,0.00004301333,0.0002041205,0.6119251,0.000299247,0.000283525,0.0001042195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963953,0.002306315,0.00003479029,0.0004185255,0.00007702348,0.0005492667,0.00002715245,0.00001094837,0.0001807109],"genre_scores_gemma":[0.9970341,0.002046111,0.000351557,0.0003598805,0.00001069057,0.00003237262,0.000009339507,0.00001171523,0.0001441952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3233626,"threshold_uncertainty_score":0.7262755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004642978571765483,"score_gpt":0.2868136011279019,"score_spread":0.2821706225561365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}