{"id":"W4412395910","doi":"10.1101/2025.07.08.663799","title":"NDUFS2 (NADH:Ubiquinone oxidoreductase core subunit S2) in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiovascular Conditions and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Electron transport chain; Oxidoreductase; Protein subunit; Ductus arteriosus; Mitochondrion; Chemistry; Mitochondrial respiratory chain; NADH dehydrogenase; Coenzyme Q – cytochrome c reductase; Reactive oxygen species; Oxygen; Cell biology; Biophysics; Biochemistry; Biology; Enzyme; Internal medicine; Medicine; Gene; Cytochrome c","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004016848,0.0007344553,0.001602856,0.001044019,0.0001572033,0.00004809984,0.0003887003,0.0005808909,0.0002046718],"category_scores_gemma":[0.0001369765,0.0008339128,0.0006249395,0.001010726,0.0002383869,0.00007619201,0.0002013041,0.0007726416,0.00002220626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006156028,"about_ca_system_score_gemma":0.001298945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005699125,"about_ca_topic_score_gemma":0.00006538686,"domain_scores_codex":[0.9959909,0.0002184728,0.0009896412,0.001351913,0.0006498788,0.0007991709],"domain_scores_gemma":[0.9964873,0.00009194324,0.000206868,0.001947165,0.0007818424,0.0004849101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000665304,0.0008646097,0.001480509,0.0009388279,0.0005865452,0.002001725,0.00006843688,0.00003277166,0.9926922,0.0003651215,0.0003003455,0.000003554016],"study_design_scores_gemma":[0.004082873,0.0005059394,0.4679229,0.001586661,0.001164483,4.768444e-7,0.00002404396,0.00003216519,0.5218114,0.000008020752,0.00202534,0.000835722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932464,0.0005585953,0.0002919757,0.0004247724,0.0007233085,0.002188657,0.002407037,0.00013452,0.00002473419],"genre_scores_gemma":[0.9967231,0.0000789948,0.00193044,0.0002967485,0.0003865885,0.0004255815,0.00001994659,0.0001138588,0.00002481137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4708808,"threshold_uncertainty_score":0.9994112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296402587860231,"score_gpt":0.2782541989638093,"score_spread":0.255290173085207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}