{"id":"W4412395910","doi":"10.1101/2025.07.08.663799","title":"NDUFS2 (NADH:Ubiquinone oxidoreductase core subunit S2) in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiovascular Conditions and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Electron transport chain; Oxidoreductase; Protein subunit; Ductus arteriosus; Mitochondrion; Chemistry; Mitochondrial respiratory chain; NADH dehydrogenase; Coenzyme Q – cytochrome c reductase; Reactive oxygen species; Oxygen; Cell biology; Biophysics; Biochemistry; Biology; Enzyme; Internal medicine; Medicine; Gene; Cytochrome c","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838386,0.0002357213,0.0002471275,0.0001515509,0.0002200709,0.0003242095,0.0001280067,0.0003339766,0.001169926],"category_scores_gemma":[0.0002132528,0.0001647399,0.0001865868,0.0001426594,0.0001786007,0.0001601787,0.0001802872,0.0002511298,0.0003222014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832391,"about_ca_system_score_gemma":0.000137066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007087674,"about_ca_topic_score_gemma":0.0007151033,"domain_scores_codex":[0.9998349,0.00003568745,0.00001731976,0.00003714721,0.00003877417,0.00003618489],"domain_scores_gemma":[0.9998556,0.00002273255,0.00004062118,0.00001330472,0.00002386865,0.00004382194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002459388,0.00001309585,0.001346285,0.00003019741,0.000007178639,0.00009942341,0.00001737495,0.00003495323,0.9977355,0.00002949862,0.00007422675,0.0003663137],"study_design_scores_gemma":[0.00007235821,0.0005043025,0.09733462,0.00001637582,0.00005192358,0.001256629,0.0002327793,0.002022046,0.8931401,0.000116253,0.005244681,0.00000782856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965265,0.001829973,0.0006960642,0.0001727508,0.00004352629,0.00001408434,0.0002255597,0.00001941747,0.000472073],"genre_scores_gemma":[0.9976394,0.0004943204,0.0004210039,0.00003381734,0.00001894959,0.00001999032,0.0003991341,0.000003564597,0.0009698413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169926,"threshold_uncertainty_score":0.00391376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296402587860231,"score_gpt":0.2782541989638093,"score_spread":0.255290173085207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}