{"id":"W4412406407","doi":"10.1186/s13054-025-05554-w","title":"Volatile agents: when generalization doesn’t help","year":2025,"lang":"en","type":"letter","venue":"Critical Care","topic":"Intensive Care Unit Cognitive Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Generalization; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002499514,0.0008690775,0.001252417,0.0009154785,0.006168442,0.004653992,0.001857086,0.07933176,0.0104512],"category_scores_gemma":[0.0323891,0.0006342648,0.001751358,0.0007164355,0.003484336,0.005081006,0.00220957,0.0459979,0.006800932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005507508,"about_ca_system_score_gemma":0.006040378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01041435,"about_ca_topic_score_gemma":0.02159908,"domain_scores_codex":[0.997263,0.0006244676,0.0004865905,0.0003767717,0.0006830641,0.0005660751],"domain_scores_gemma":[0.9913565,0.004658751,0.0006863262,0.0002874798,0.001334985,0.001675924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007925666,0.00007032212,0.002176147,0.00008327894,0.00004916336,0.03459952,0.0003836557,0.0001739913,0.0002254888,0.006618723,0.9360172,0.01952333],"study_design_scores_gemma":[0.0003412988,0.0001882049,0.002870847,0.001401431,0.0001012328,0.04754024,0.002008336,0.001355758,0.0004370525,0.05297465,0.8906176,0.0001633693],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007994247,0.001070827,0.00009973715,0.9824025,0.007410493,0.00001005256,0.00002528191,0.00002267912,0.008159064],"genre_scores_gemma":[0.009651756,0.00119309,0.0002994332,0.9535595,0.02777145,0.00001928709,0.00002330673,0.00002759564,0.00745464],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07933176,"threshold_uncertainty_score":0.03996003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622944296897838,"score_gpt":0.3240543806429299,"score_spread":0.2978249376739515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}