{"id":"W4412410957","doi":"10.1002/npr2.70039","title":"Primary Progressive Multiple Sclerosis: New Therapeutic Approaches","year":2025,"lang":"en","type":"review","venue":"Neuropsychopharmacology Reports","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brandon Regional Health Authority; Winnipeg Regional Health Authority","funders":"","keywords":"Medicine; Multiple sclerosis; Remyelination; Fingolimod; Neuroprotection; Alemtuzumab; Ocrelizumab; Neuroinflammation; Glatiramer acetate; Oncology; Internal medicine; Bioinformatics; Immunology; Central nervous system; Transplantation; Myelin; Lymphoma; Inflammation; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008189845,0.0009633178,0.001660778,0.003274851,0.0002873755,0.001127242,0.000897489,0.001199548,0.005372474],"category_scores_gemma":[0.0008254754,0.0002658655,0.0007392135,0.002270221,0.0006169704,0.001575986,0.0007487108,0.001989708,0.001861652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007738567,"about_ca_system_score_gemma":0.001223122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203679,"about_ca_topic_score_gemma":0.002236998,"domain_scores_codex":[0.9997163,0.0000625925,0.00004656127,0.00004572436,0.0001048326,0.00002385674],"domain_scores_gemma":[0.9996175,0.0001932812,0.00005246946,0.00001397574,0.00009132668,0.00003155666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001011781,0.00008308308,0.00009625277,0.03120977,0.0001249937,0.0002125428,0.00007073428,0.0002351818,0.0007424798,0.003336731,0.02309695,0.9406902],"study_design_scores_gemma":[0.0000657459,0.0001356893,0.0006563709,0.01454329,0.0002709949,0.001735584,0.0001060083,0.00007847448,0.0002679685,0.002794085,0.9793255,0.00002040166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003599825,0.9992813,0.0000337064,0.0001968821,0.00008896618,0.00000280683,0.00000499845,0.00000338946,0.0003519194],"genre_scores_gemma":[0.0003735728,0.9990034,0.00009183714,0.0001781006,0.0001225701,0.000005165723,0.00001100619,7.86776e-7,0.0002137133],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005372474,"threshold_uncertainty_score":0.01797271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2308157057683825,"score_gpt":0.4032753419285918,"score_spread":0.1724596361602093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}