{"id":"W4412413467","doi":"10.1080/17425255.2025.2535177","title":"The on-going quest for a long-acting oral form of levodopa","year":2025,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Canada; Weston Brain Institute; Canadian Institutes of Health Research; Parkinson Québec","keywords":"Levodopa; Medicine; Psychology; Intensive care medicine; Business; Pharmacology; Disease; Internal medicine; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005428836,0.0005386121,0.0008980912,0.0008047935,0.0001979117,0.0009463477,0.0006441689,0.001281559,0.007279512],"category_scores_gemma":[0.0008503315,0.0001429115,0.000582471,0.0006698613,0.0004014914,0.001256731,0.0004935803,0.00247675,0.004466569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004578465,"about_ca_system_score_gemma":0.0007545908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008911068,"about_ca_topic_score_gemma":0.001484136,"domain_scores_codex":[0.9997545,0.00004520036,0.00002143875,0.00004525229,0.0001151688,0.00001847352],"domain_scores_gemma":[0.9996752,0.0001247587,0.00004996571,0.00001176676,0.0001164217,0.00002193332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007583144,0.00003685684,0.00009421827,0.0125053,0.00007393809,0.0001501043,0.00004861648,0.0001657965,0.002700864,0.00653745,0.06074137,0.9168696],"study_design_scores_gemma":[0.00001278576,0.00005695056,0.0002387304,0.002689889,0.00005056861,0.0006848683,0.0000284487,0.00005105216,0.0003441254,0.001700278,0.9941341,0.000008246727],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001947949,0.9929832,0.000378585,0.002304414,0.0007782527,0.000008091542,0.00005022494,0.00001769148,0.003284702],"genre_scores_gemma":[0.001447751,0.9936705,0.0004484357,0.001393629,0.0006199811,0.00001062502,0.00008239435,0.000006211405,0.002320416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007279512,"threshold_uncertainty_score":0.02435243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06573145670085147,"score_gpt":0.405163790300276,"score_spread":0.3394323335994246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}