{"id":"W4412416720","doi":"10.1002/alz.70347","title":"Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University; Sunnybrook Health Science Centre","funders":"National Institutes of Health; Avid Radiopharmaceuticals; Cerveau Technologies; BrightFocus Foundation; National Institute on Aging; Eli Lilly and Company; GHR Foundation; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Positron emission tomography; Pittsburgh compound B; Medicine; Neuroimaging; Nuclear medicine; Magnetic resonance imaging; Atrophy; Standardized uptake value; Pet imaging; Internal medicine; Psychology; Disease; Alzheimer's disease; Radiology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001365099,0.000412568,0.0008914622,0.0001197037,0.0001474282,0.0005757625,0.0002717792,0.0004501064,0.0026483],"category_scores_gemma":[0.0012831,0.0001439537,0.0006115877,0.0002131876,0.0002716072,0.0004724947,0.0001489019,0.001129783,0.000319147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430661,"about_ca_system_score_gemma":0.0003973856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526169,"about_ca_topic_score_gemma":0.001325616,"domain_scores_codex":[0.9994255,0.0003562956,0.00003198833,0.00007085932,0.00004173379,0.00007375157],"domain_scores_gemma":[0.9995054,0.0001494846,0.000150457,0.00003660383,0.00003823259,0.0001198114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8456859,0.002084008,0.0140063,0.001481955,0.00423453,0.0001817128,0.0001327681,0.001231394,0.01706745,0.0004458528,0.003877842,0.1095703],"study_design_scores_gemma":[0.5701368,0.1956829,0.2026901,0.0004093372,0.007883694,0.0008331038,0.0001713727,0.003364609,0.008107451,0.001470398,0.009137834,0.0001123437],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879515,0.007466265,0.0001951837,0.0004912625,0.00007670084,0.0001925289,0.0005034037,0.00004144959,0.003081735],"genre_scores_gemma":[0.9968749,0.0011498,0.0002764112,0.0002471664,0.00005435795,0.000182533,0.0004985657,0.000009143558,0.0007072471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0026483,"threshold_uncertainty_score":0.008859456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03148899764827114,"score_gpt":0.323981305307289,"score_spread":0.2924923076590179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}