{"id":"W4412418870","doi":"10.1016/j.ahj.2025.07.010","title":"The effects of low-dose colchicine on the progression of aortic valve stenosis: Rationale, design, and baseline characteristics of the Colchicine and Inflammation in Aortic Stenosis (CHIANTI) trial","year":2025,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"","keywords":"Medicine; Colchicine; Stenosis; Cardiology; Internal medicine; Aortic valve stenosis; Inflammation; Aortic valve; Aortic valve replacement; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003700508,0.001941155,0.003349242,0.000323084,0.0006481805,0.001175995,0.0009753652,0.002339424,0.004689691],"category_scores_gemma":[0.002601122,0.0006214147,0.001938683,0.0005272283,0.001452262,0.0007866829,0.0003616261,0.002526305,0.0007107743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006314198,"about_ca_system_score_gemma":0.001211535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006862218,"about_ca_topic_score_gemma":0.001671199,"domain_scores_codex":[0.9981009,0.001292386,0.0001158353,0.0002325355,0.0000957392,0.0001625286],"domain_scores_gemma":[0.9981261,0.000612202,0.0003671401,0.0001287934,0.0001834609,0.0005822474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9871125,0.002695337,0.001365536,0.00109549,0.001073179,0.00004397474,0.00002980254,0.0001659482,0.001933246,0.0000907275,0.0004656243,0.003928645],"study_design_scores_gemma":[0.9280842,0.06338071,0.004603373,0.00009207474,0.002044745,0.00004409015,0.00002771708,0.0003481299,0.000466084,0.0002067326,0.0006777073,0.00002437256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9562343,0.02110148,0.001169107,0.002205855,0.0009819021,0.01204379,0.00210339,0.00009803418,0.004062143],"genre_scores_gemma":[0.9785338,0.003773719,0.002051797,0.001387479,0.000956971,0.01017541,0.001078211,0.00001957325,0.002023026],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.004689691,"threshold_uncertainty_score":0.01957041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052445819848075,"score_gpt":0.3217473568364166,"score_spread":0.3112228986379358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}