{"id":"W4412420798","doi":"10.21203/rs.3.rs-6791339/v1","title":"Storage Protein-Mediated Translation Control Links Juvenile Diet to Longevity in Drosophila","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; RIKEN; RIKEN Center for Biosystems Dynamics Research; Japan Science and Technology Agency; Japan Society for the Promotion of Science","keywords":"Longevity; Biology; Juvenile; Larva; Protein biosynthesis; Amino acid; Translation (biology); Model organism; Ribosome biogenesis; Tyrosine; Organism; Genetics; Biochemistry; Ribosome; Ecology; Gene; Messenger RNA; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556559,0.0003548996,0.0002402724,0.0001848457,0.0001303625,0.0004876628,0.0001775988,0.0002672014,0.00117349],"category_scores_gemma":[0.0001941322,0.0001391503,0.0001784143,0.0001647832,0.0003223385,0.0004020141,0.000204533,0.0003162617,0.0003256491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002778921,"about_ca_system_score_gemma":0.0001818713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005957113,"about_ca_topic_score_gemma":0.0008130256,"domain_scores_codex":[0.9999453,0.000006771476,0.000003487842,0.00002225278,0.00001173001,0.00001057295],"domain_scores_gemma":[0.9998851,0.00003136287,0.0000362551,0.0000193055,0.0000110423,0.00001687492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003451206,0.00002308526,0.0009996025,0.00008817482,0.00001577548,0.0001242155,0.00002881852,0.001016248,0.9860386,0.003427873,0.0007396248,0.007152897],"study_design_scores_gemma":[0.00007329078,0.0002116367,0.03195152,0.00001804081,0.00004481269,0.0003084203,0.00005671384,0.03171599,0.9233933,0.008587379,0.003611752,0.00002717537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749814,0.00266458,0.01689524,0.0004375553,0.00008216133,0.000009321936,0.001088617,0.0004699512,0.003371163],"genre_scores_gemma":[0.9888483,0.001184991,0.005041466,0.00006494803,0.00002197527,0.00001153414,0.0007705393,0.00009966247,0.003956595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117349,"threshold_uncertainty_score":0.003925741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437355214495848,"score_gpt":0.3408869976313472,"score_spread":0.3065134454863887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}