{"id":"W4412424527","doi":"10.1016/j.inpsyc.2025.100113","title":"The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex","year":2025,"lang":"en","type":"article","venue":"International Psychogeriatrics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Saskatchewan","funders":"National Institute of Mental Health; National Institutes of Health; National Institute of Mental Health and Neurosciences","keywords":"Depression (economics); Senescence; Confounding; Biomarker; Internal medicine; Medicine; Phenotype; Psychology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004751725,0.0002133188,0.0003010237,0.0002766947,0.0001059243,0.00005056176,0.0002641494,0.0002016029,0.000061838],"category_scores_gemma":[0.0003422745,0.0001726138,0.0000706361,0.0008344339,0.000120889,0.0001045465,0.00007429317,0.0002898254,0.000004912938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223168,"about_ca_system_score_gemma":0.0001598154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001565069,"about_ca_topic_score_gemma":0.00002242592,"domain_scores_codex":[0.9980865,0.0001048497,0.0005786774,0.0004456775,0.0005101366,0.0002741411],"domain_scores_gemma":[0.9987463,0.0002383406,0.0002254007,0.0002994696,0.0004033364,0.00008718138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001162032,0.0005152697,0.6216258,0.00009901276,0.0002575874,0.00003047907,0.0005401949,0.00001194707,0.3414042,0.0002968019,0.02240064,0.01165604],"study_design_scores_gemma":[0.009976123,0.0001910134,0.7767321,0.001165906,0.000216382,0.00002611318,0.0005788662,0.05889159,0.1068296,0.00198311,0.04257816,0.0008310465],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988396,0.002411047,0.003163517,0.001327171,0.0009232967,0.000434764,0.00009730092,0.00006235793,0.00318452],"genre_scores_gemma":[0.9936051,0.001435415,0.0001703032,0.0006335233,0.00005224561,0.00001590169,0.00009399374,0.00001972082,0.003973829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2345747,"threshold_uncertainty_score":0.7038987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006848514221675493,"score_gpt":0.2647241463521516,"score_spread":0.2578756321304762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}